Evidence map›Paper›PMID 36929286›Full record

ArticleMolecular biology reports2023

Prognostic significance of the genetic variant of lymphotoxin alpha (p.Thr60Asn) in egyptian patients with advanced hepatocellular carcinoma.

Maha Alhelf, Rasha M S Shoaib, Afaf Elsaid, Nermeen Bastawy, Nanis S Elbeltagy, Eman T Salem, Sherif Refaat, Eman H Abuelnadar

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Maha AlhelfBiotechnology School, Nile University, Giza, Egypt.
Rasha M S ShoaibFood and Dairy Sciences and Technology Department, Faculty of Environmental Agricultural Sciences, Arish University, 45511, North Sinai, Egypt. rashashoaib83@yahoo.com.ORCID http://orcid.org/0000-0001-5150-7491
Afaf ElsaidGenetics Unit, Mansoura University, Children Hospital, Mansoura, Egypt.
Nermeen BastawyMedical Physiology Department, Faculty of Medicine, Cairo University, Giza, Egypt.
Nanis S ElbeltagyDepartment of Laboratories, Faculty of Medicine, Mansoura University, Children Hospital, Mansoura, Egypt.
Eman T SalemDepartment of Basic Science, Faculty of Physical Therapy, Horus University, Damietta, Egypt.
Sherif RefaatOncology Center, Mansoura University, Mansoura, Egypt.
Eman H AbuelnadarDepartment of Laboratories, Faculty of Medicine, Mansoura University, Children Hospital, Mansoura, Egypt.
Children's Hospital Mansoura University · EGCairo University · EGArish University · EGDamietta University · EGMansoura University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatocellular carcinoma (HCC) is one of the most common malignancies worldwide in terms of mortality, and susceptibility is attributed to genetic, lifestyle, and environmental factors. Lymphotoxin alpha (LTA) has a crucial role in communicating the lymphocytes with stromal cells and provoking cytotoxic effects on the cancer cells. There are no reports on the contribution of the LTA (c.179 C>A; p.Thr60Asn; rs1041981) gene polymorphism to HCC susceptibility. The main aim of this study is to investigate the association of LTA (c.179 C>A; p.Thr60Asn; rs1041981) variant with the HCC risk in the Egyptian population.

methodsThis case-control study included 317 participants (111 HCC patients, and 206 healthy controls). The LTA (c.179 C>A; p.Thr60Asn; rs1041981) polymorphism was assessed by tetra-primer amplification refractory mutation system polymerase chain reaction (T-ARMS-PCR) technique.

resultsThe frequencies of the dominant and recessive models (CA + AA; AA) of the LTA (c.179 C>A; p.Thr60Asn; rs1041981) variant were statistically significant among HCC patients in comparison to controls (p = 0.01; p = 0.007; respectively). The A-allele of LTA (c.179 C>A; p.Thr60Asn; rs1041981) variant was statistically significant in HCC patients in comparison to controls (p ˂ 0.001).

conclusionThe LTA (c.179 C>A; p.Thr60Asn; rs1041981) polymorphism was independently associated with an increased risk for hepatocellular carcinoma in the Egyptian population.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsCase-Control StudiesEgyptGenetic Predisposition to DiseaseGenotypeHumansLymphotoxin-alphaPolymorphism, Single NucleotidePrognosisLymphotoxin-alphaHepatocellular carcinomaLTA, Gene polymorphismLymphotoxin alpha

Identifiers

PMID36929286
PMCPMC10147750
OpenAlexW4327676929

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