Evidence map›Paper›PMID 36929219›Full record

ReviewCell and tissue research2023

New developments in prion disease research using genetically modified mouse models.

Julianna L Sun, Glenn C Telling

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cell and tissue research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Julianna L SunPrion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, USA.
Glenn C TellingPrion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, USA. glenn.telling@colostate.edu.ORCID http://orcid.org/0000-0002-6294-1805
Colorado State University · US

Funding

Characterizing the strain and host range properties of prions causing emergent forms of chronic wasting diseaseR01NS109376 · NINDS · COLORADO STATE UNIVERSITY · PI TELLING, GLENN C · 2018 to 2022
$2.4M
Addressing the mechanisms of prion strain evolution and its effect on interspecies transmissionR01NS121682 · NINDS · COLORADO STATE UNIVERSITY · PI TELLING, GLENN C · 2021 to 2023
$1.5M
NIH HHS 1R01NS109376NIH HHS 1R01NS121682NIH HHS PO1-0011877A
6 · The paper itself

Abstract

While much of what we know about the general principles of protein-based information transfer derives from studies of experimentally adapted rodent prions, these laboratory strains are limited in their ability to recapitulate features of human and animal prions and the diseases they produce. Here, we review how recent approaches using genetically modified mice have informed our understanding of naturally occurring prion diseases, their strain properties, and the factors controlling their transmission and evolution. In light of the increasing importance of chronic wasting disease, the application of mouse transgenesis to study this burgeoning and highly contagious prion disorder, in particular recent insights derived from gene-targeting approaches, will be a major focus of this review.

Indexed as

DeerPrion DiseasesPrionsWasting Disease, ChronicAnimalsDisease Models, AnimalGene TargetingHumansMiceMice, TransgenicPrionsChronic wasting diseaseGene-targeted micePrionsStrainsTransgenic mice

Identifiers

PMID36929219
OpenAlexW4327545516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.