Evidence map›Paper›PMID 36929211›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2023

Characterization of neuroinflammation pattern in anti-LGI1 encephalitis based on TSPO PET and symptom clustering analysis.

Jingguo Wang, Jingjie Ge, Lei Jin, Bo Deng, Weijun Tang, Hai Yu, Xiang Zhang, Xiaoni Liu, Le Xue, Chuantao Zuo and 1 more

Abstract read
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Article in European journal of nuclear medicine and molecular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Neuroinflammation in GAD65 Antibody-Associated Epilepsy Measured Using [Annals of clinical and translational neurology · 2026
    Article
  3. Article
  4. Article
  5. MedComm · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Microglial Activation Visualized by [European journal of neurology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Jingguo Wang *Department of Neurology and Institute of Neurology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, China.
Jingjie Ge *Department of Nuclear Medicine/PET Center, Huashan Hospital, Fudan University, 518 East Wuzhong Road, Shanghai, 200235, China.
Lei JinDepartment of Neurology and Institute of Neurology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, China.
Bo DengDepartment of Neurology and Institute of Neurology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, China.
Weijun TangDepartment of Radiology, Huashan Hospital, Shanghai, 200040, China.
Hai YuDepartment of Neurology and Institute of Neurology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, China.
Xiang ZhangDepartment of Neurology and Institute of Neurology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, China.
Xiaoni LiuDepartment of Neurology and Institute of Neurology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, China.
Le XueDepartment of Nuclear Medicine, the Second Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.
Chuantao ZuoDepartment of Nuclear Medicine/PET Center, Huashan Hospital, Fudan University, 518 East Wuzhong Road, Shanghai, 200235, China. zuochuantao2000@126.com.
Xiangjun ChenDepartment of Neurology and Institute of Neurology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, China. xiangjchen@fudan.edu.cn.ORCID 0000-0002-8108-9013
Fudan University · CNHuashan Hospital · CNSecond Affiliated Hospital of Zhejiang University · CN

Funding

Clinical Research Plan of SHDC No. SHDC2020CR2027BClinical Research Plan of SHDC SHDC2020CR1038BNational Natural Science Foundation of China No. 81971641Research project of Shanghai Health Commission 2020YJZX0111Science and Technology Innovation Plan Of Shanghai Science and Technology Commission 21Y11903300
6 · The paper itself

Abstract

purposeTSPO PET with radioligand [

methodsTwenty patients with anti-LGI1 encephalitis from the autoimmune encephalitis cohort in Huashan Hospital and ten with other AIE and non-inflammatory diseases that underwent TSPO PET imaging were included in the current study. Increased regional [

resultsIncreased regional retention of [

conclusionsAnti-LGI1 encephalitis had a distinctive molecular imaging pattern presented by TSPO PET scan. LGI1-AIE patients with higher retention of [

Indexed as

Autoimmune Diseases of the Nervous SystemEncephalitisGliomaHashimoto DiseaseHumansIntracellular Signaling Peptides and ProteinsLeucineNeuroinflammatory DiseasesPositron-Emission TomographyReceptors, GABASeizuresIntracellular Signaling Peptides and ProteinsLeucineReceptors, GABATSPO protein, human[18F]DPA-714Anti-LGI1 encephalitisMicroglial activationMolecular imagingPhenotype clustering

Identifiers

PMID36929211
OpenAlexW4327685928

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.