Evidence map›Paper›PMID 36929102›Full record

ArticleEuropean journal of immunology2023

The medulla controls effector primed γδT-cell development in the adult mouse thymus.

Kieran D James, Andrea J White, William E Jenkinson, Graham Anderson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Assembling the thymus medulla: Development and function of epithelial cell heterogeneity.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kieran D JamesInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Andrea J WhiteInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
William E JenkinsonInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Graham AndersonInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.ORCID 0000-0002-2917-4085
University of Birmingham · GB

Funding

Medical Research Council MR/T029765/1
6 · The paper itself

Abstract

γδT cells are produced in the thymus throughout life and provide immunity at epithelial-rich sites. Unlike conventional αβT cells, γδT-cell development involves intrathymic acquisition of effector function, with priming for either IL17 or IFN-γ production occurring during embryonic or adult life, respectively. How the thymus controls effector-primed γδT-cell generation in adulthood is poorly understood. Here, we distinguished de novo γδT cells from those undergoing thymus recirculation and/or retention using Rag2GFP mice alongside markers of maturation/effector priming including CD24, CD25, CD73, and IFN-γ, the latter by crossing with IFN-γ

Indexed as

Interferon-gammaThymus GlandAnimalsCell DifferentiationMiceReceptors, Antigen, T-Cell, gamma-deltaInterferon-gammaReceptors, Antigen, T-Cell, gamma-deltaCCL21MedullaThymusγδT cells

Identifiers

PMID36929102
PMCPMC10947249
OpenAlexW4327544445

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.