ArticleEuropean journal of applied physiology2023
Serum klotho concentrations in older men with hypertension or type 2 diabetes during prolonged exercise in temperate and hot conditions.
Article in European journal of applied physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.
- Effects of acute, subacute, and chronic exercise on plasma s-Klotho levels: a systematic review and meta-analysis.Journal of physiology and biochemistry · 2026Pooled it
- Seven days of warm-water immersion enhances resting irisin and BDNF, but not klotho, in older men.Experimental physiology · 2026Article
- Brief extreme passive heat exposure leads to elevated biomarkers of systemic inflammation and acute kidney injury in older vs young adults.European journal of applied physiology · 2025Article
- Unveiling the Prognostic Power of HRR in ICU-Admitted COPD Patients: A MIMIC-IV Database Study.International journal of chronic obstructive pulmonary disease · 2025Article
- Experimental research in environmentally induced hyperthermic older persons: A systematic quantitative literature review mapping the available evidence.Temperature (Austin, Tex.) · 2024Article
- Colliding crises: The global diabetes pandemic meets climate change-A scoping review.The journal of climate change and healthReview
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeKlotho is a cytoprotective protein that increases during acute physiological stressors (e.g., exercise heat stress), although age-related declines in klotho may underlie cellular vulnerability to heat stress. The present study aimed to compare serum klotho in healthy older men and men with type 2 diabetes (T2D) or hypertension (HTN) during prolonged exercise in temperate or hot conditions.
methodsWe evaluated serum klotho in 12 healthy older men (mean [SD]; 59 years [4]), 10 men with HTN (60 years [4]), and 9 men with T2D (60 years [5]) before and after 180 min of moderate-intensity (fixed metabolic rate of 200 W/m
resultsTotal exercise duration was reduced during the hot condition in older men with HTN and T2D than healthy older men (both p ≤ 0.049), despite similar core temperatures, HR, and HRR. Klotho was higher than rest following exercise in the heat in healthy older men (+ 191 pg/mL [189]; p < 0.001) and responses were greater (p = 0.036) than men with HTN (+ 118 pg/mL [49]; p = 0.030), although klotho did not increase in men with T2D (+ 4 pg/mL [71]; p ≥ 0.638).
conclusionGiven klotho's role in cytoprotection, older men with HTN and especially T2D may be at increased cellular vulnerability to prolonged exercise or physically demanding exercise in the heat.
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