Evidence map›Paper›PMID 36928990›Full record

ArticleActa obstetricia et gynecologica Scandinavica2023

Severe COVID-19 during pregnancy in Sweden, Norway, and Denmark.

Anne K Örtqvist, Maria C Magnus, Anna J M Aabakke, Stine Kjaer Urhoj, Anne Vinkel Hansen, Anne-Marie Nybo Andersen, Lone Krebs, Karin Pettersson, Siri E Håberg, Olof Stephansson

Open access · diamondAbstract read
In one paragraph

Article in Acta obstetricia et gynecologica Scandinavica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Pregnancy and SARS-COV2 Infection.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024
    Article
  8. Article
  9. Severe COVID-19 during pregnancy in Sweden, Norway, and Denmark.Acta obstetricia et gynecologica Scandinavica · 2023
    Article
  10. Observational
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Anne K ÖrtqvistClinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-9019-9233
Maria C MagnusCenter for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0002-0568-3774
Anna J M AabakkeDepartment of Obstetrics and Gynecology, Copenhagen University Hospital-Holbaek, Holbaek, Denmark.ORCID 0000-0003-4754-506X
Stine Kjaer UrhojDepartment of Public Health, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-2069-9723
Anne Vinkel HansenDepartment of Public Health, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-4523-3521
Anne-Marie Nybo AndersenDepartment of Public Health, University of Copenhagen, Copenhagen, Denmark.
Lone KrebsDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-5433-4776
Karin PetterssonDepartment of Clinical Science Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Siri E HåbergCenter for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0002-2199-5225
Olof StephanssonClinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-1528-4563
University of Copenhagen · DKKarolinska University Hospital · SENorwegian Institute of Public Health · NOKarolinska Institutet · SE

Funding

Wellcome Trust 105545
6 · The paper itself

Abstract

introductionPregnancy is a risk factor for severe coronavirus disease 2019 (COVID-19) and adverse pregnancy outcomes. We aimed to explore maternal characteristics, pregnancy outcomes, vaccination status, and virus variants among pregnant women admitted to intensive care units (ICU) with severe COVID-19. MATERIAL AND

methodsWe identified pregnant women admitted to ICU in Sweden (n = 96), Norway (n = 31), and Denmark (n = 16) because of severe COVID-19, from national registers and clinical databases between March 2020 and February 2022 (Denmark), August 2022 (Sweden), or December 2022 (Norway). Their background characteristics, pregnancy outcome, and vaccination status were compared with all birthing women and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test-positive pregnant women during the same time period. We calculated the number admitted to ICU per 10 000 birthing and per 1000 SARS-CoV-2 test-positive women during the Index, Alpha, Delta, and Omicron periods.

resultsWomen admitted to ICU had a higher mean body mass index, were more often of non-Scandinavian origin, had on average lower education and income levels, had a higher proportion of chronic and pregnancy-related conditions, delivered preterm, had neonates with low Apgar scores, and had more infants admitted to neonatal care, compared with all birthing and test-positive pregnant women. Of those admitted to ICU, only 7% had been vaccinated before admission. Overall, the highest proportion of women admitted to ICU per birthing was during the Delta period (4.1 per 10 000 birthing women). In Norway, the highest proportion admitted to ICU per test-positive pregnant women was during the Delta period (17.8 per 1000 test-positive), whereas the highest proportion of admitted per test-positive in Sweden and Denmark was seen during the Index period (15.4 and 8.9 per 1000 test-positive, respectively).

conclusionsAdmission to ICU because of COVID-19 in pregnancy was a rare event in the Scandinavian countries, but women who were unvaccinated, of non-Scandinavian origin, and with lower socio-economic status were at higher risk of admission to ICU. In addition, women admitted to ICU for COVID-19 had higher risk of adverse pregnancy outcomes.

Indexed as

COVID-19Pregnancy Complications, InfectiousDenmarkFemaleHumansInfant, NewbornNorwayPregnancyPregnancy OutcomeSARS-CoV-2Swedenintensive care unitregistervaccinationvirus variant

Identifiers

PMID36928990
PMCPMC10201957
OpenAlexW4327675691

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.