Evidence map›Paper›PMID 36928415›Full record

ArticleNature immunology2023

Exhausted intratumoral Vδ2

Chiara Rancan, Marcel Arias-Badia, Pranay Dogra, Brandon Chen, Dvir Aran, Hai Yang, Diamond Luong, Arielle Ilano, Jacky Li, Hewitt Chang and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Nature immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 73 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. γδ T cells and cancer.The Journal of clinical investigation · 2026
    Review
  5. γδ T cells in colorectal and liver cancer.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Functionally heterogeneous intratumoral CD4Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  20. Immune checkpoint TIM-3 in tumor immunotherapy.Acta biochimica et biophysica Sinica · 2026
    Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Chiara Rancan *Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, USA.
Marcel Arias-Badia *Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, USA.ORCID 0000-0003-2270-0676
Pranay DograDepartment of Microbiology and Immunology, Columbia University Medical Center, New York, NY, USA.
Brandon ChenDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, USA.
Dvir AranThe Taub Faculty of Computer Science and Faculty of Biology, Technion-Israel Institute of Technology, Haifa, Israel.ORCID 0000-0001-6334-5039
Hai YangDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, USA.
Diamond LuongDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, USA.ORCID 0000-0001-6832-5408
Arielle IlanoDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, USA.
Jacky LiDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, USA.
Hewitt ChangDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, USA.ORCID 0000-0001-9760-2304
Serena S KwekDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, USA.
Li ZhangDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, USA.
Lewis L LanierHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.ORCID 0000-0003-1308-3952
Maxwell V MengDepartment of Urology, University of California, San Francisco, CA, USA.
Donna L FarberDepartment of Microbiology and Immunology, Columbia University Medical Center, New York, NY, USA.ORCID 0000-0001-8236-9183
Lawrence FongDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, USA. lawrence.fong@ucsf.edu.ORCID 0000-0002-6428-428X
University of California, San Francisco · USColumbia University Irving Medical Center · USTechnion – Israel Institute of Technology · IL

Funding

Transcriptomics and Repertoire ProfilingP01AI106697 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber · 2013 to 2026
$31.3M
Viral Assays CoreU19AI128949 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Peter Alan Sims · 2017 to 2026
$26.4M
Determinants of response to cancer immunotherapyR35CA253175 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Lawrence Fong · 2021 to 2026
$5.8M
Molecular and immune drivers of immunotherapy responsiveness in prostate cancerU01CA233100 · NCI · DANA-FARBER CANCER INST · PI FONG, LAWRENCE, VAN ALLEN, ELIEZER M · 2018 to 2022
$4.2M
Investigation of the landscape of immunosequencing and its clinical relevance through novel immunoinformatic approachesR01LM013763 · NLM · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZHANG, LI · 2022 to 2025
$1.4M
Computational approaches to unravel immune receptor sequencing for cancer immunotherapyR21CA264381 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZHANG, LI · 2021 to 2022
$384k
NCI NIH HHS R21 CA264381NCI NIH HHS R35 CA253175NCI NIH HHS U01 CA233100NIAID NIH HHS P01 AI106697NIAID NIH HHS U19 AI128949NLM NIH HHS R01 LM013763
6 · The paper itself

Abstract

Gamma delta (γδ) T cells reside within human tissues including tumors, but their function in mediating antitumor responses to immune checkpoint inhibition is unknown. Here we show that kidney cancers are infiltrated by Vδ2

Indexed as

CD8-Positive T-LymphocytesKidney NeoplasmsHumansProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsTumor MicroenvironmentProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-Cell, gamma-delta

Identifiers

PMID36928415
PMCPMC10063448
OpenAlexW4327568900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.