ArticleNature communications2023
Electrochemical oxidative difunctionalization of diazo compounds with two different nucleophiles.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Modular Access to α-Tertiary Amines: Electrochemical Tandem Di-Functionalization of Olefins With Ammonia Surrogates and Amino Acids.Angewandte Chemie (International ed. in English) · 2026Article
- Synthesis of Aryl and Heteroaryl Diazophosphonates via Palladium-Catalyzed Cross-Coupling and Their Application in Rhodium-Catalyzed Cyclopropanation.The Journal of organic chemistry · 2026Article
- Geminal Difunctionalization of Ketones via C─S Bond Insertion of Photogenerated Donor-Donor Diazo Compounds.Angewandte Chemie (International ed. in English) · 2026Article
- Bromination Functionalization of Diazo Compounds with CBrOrganic letters · 2026Article
- [2,3]-Sigmatropic rearrangement with [1.1.1]propellane.Nature communications · 2025Article
- Photoelectrocatalytic Cl-mediated C(spNature communications · 2025Article
- DigiChemTree enables programmable light-induced carbene generation for on demand chemical synthesis.Communications chemistry · 2024Article
- Electrochemical stereoselective synthesis of polysubstituted 1,4-dicarbonylChemical science · 2024Article
- Skeletal Editing: Ring Insertion for Direct Access to Heterocycles.Molecules (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the fast development of synthetic chemistry, the introduction of functional group into organic molecules has attracted increasing attention. In these reactions, the difunctionalization of unsaturated bonds, traditionally with one nucleophile and one electrophile, is a powerful strategy for the chemical synthesis. In this work, we develop a different path of electrochemical oxidative difunctionalization of diazo compounds with two different nucleophiles. Under metal-free and external oxidant-free conditions, a series of structurally diverse heteroatom-containing compounds hardly synthesized by traditional methods (such as high-value alkoxy-substituted phenylthioacetates, α-thio, α-amino acid derivatives as well as α-amino, β-amino acid derivatives) are obtained in synthetically useful yields. In addition, the procedure exhibits mild reaction conditions, excellent functional-group tolerance and good efficiency on large-scale synthesis. Importantly, the protocol is also amenable to the key intermediate of bioactive molecules in a simple and practical process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.