Evidence map›Paper›PMID 36928140›Full record

ArticleOncology reports2023

Exosomal PD‑L1 promotes the formation of an immunosuppressive microenvironment in gastric diffuse large B‑cell lymphoma.

Hui Zeng, Jinfeng Wang, Biaoming Xu, Hongyu Deng, Mingjing Peng, Rilin Deng, Song Shang, Qi Hu, Junjun Li, Jinguan Lin and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Exosome tracking by magnetic resonance imaging.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Hui ZengGraduates Collaborative Training Base of Hunan Cancer Hospital, University of South China, Changsha, Hunan 410013, P.R. China.
Jinfeng WangDepartment of Gastroduodenal and Pancreatic Surgery, Translational Medicine Research Center of Liver Cancer, Laboratory of Digestive Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine & Hunan Cancer Hospital, Hunan Cancer Institute, Central South University, Changsha, Hunan 410013, P.R. China.
Biaoming XuGraduates Collaborative Training Base of Hunan Cancer Hospital, University of South China, Changsha, Hunan 410013, P.R. China.
Hongyu DengDepartment of Gastroduodenal and Pancreatic Surgery, Translational Medicine Research Center of Liver Cancer, Laboratory of Digestive Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine & Hunan Cancer Hospital, Hunan Cancer Institute, Central South University, Changsha, Hunan 410013, P.R. China.
Mingjing PengDepartment of Gastroduodenal and Pancreatic Surgery, Translational Medicine Research Center of Liver Cancer, Laboratory of Digestive Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine & Hunan Cancer Hospital, Hunan Cancer Institute, Central South University, Changsha, Hunan 410013, P.R. China.
Rilin DengInstitute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan 410082, P.R. China.
Song ShangDepartment of Gastroduodenal and Pancreatic Surgery, Translational Medicine Research Center of Liver Cancer, Laboratory of Digestive Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine & Hunan Cancer Hospital, Hunan Cancer Institute, Central South University, Changsha, Hunan 410013, P.R. China.
Qi HuGraduates Collaborative Training Base of Hunan Cancer Hospital, University of South China, Changsha, Hunan 410013, P.R. China.
Junjun LiDepartment of Gastroduodenal and Pancreatic Surgery, Translational Medicine Research Center of Liver Cancer, Laboratory of Digestive Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine & Hunan Cancer Hospital, Hunan Cancer Institute, Central South University, Changsha, Hunan 410013, P.R. China.
Jinguan LinDepartment of Gastroduodenal and Pancreatic Surgery, Translational Medicine Research Center of Liver Cancer, Laboratory of Digestive Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine & Hunan Cancer Hospital, Hunan Cancer Institute, Central South University, Changsha, Hunan 410013, P.R. China.
Haizhen ZhuDepartment of Gastroduodenal and Pancreatic Surgery, Translational Medicine Research Center of Liver Cancer, Laboratory of Digestive Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine & Hunan Cancer Hospital, Hunan Cancer Institute, Central South University, Changsha, Hunan 410013, P.R. China.
Yajun LiDepartment of Gastroduodenal and Pancreatic Surgery, Translational Medicine Research Center of Liver Cancer, Laboratory of Digestive Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine & Hunan Cancer Hospital, Hunan Cancer Institute, Central South University, Changsha, Hunan 410013, P.R. China.
Chaohui ZuoGraduates Collaborative Training Base of Hunan Cancer Hospital, University of South China, Changsha, Hunan 410013, P.R. China.
Central South University · CNHunan Cancer Hospital · CNHunan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric diffuse large B‑cell lymphoma (GDLBCL) is a common disease with an increasing incidence. However, the regulatory effect of exosomal programmed death‑ligand 1 (PD‑L1) on the immune microenvironment in GDLBCL is unclear. In the present study, the protein expression levels of exosomal PD‑L1 in the supernatants of cultured diffuse large B‑cell lymphoma (DLBCL) cells and the plasma of patients with GDLBCL was assessed using immunoblotting. Exosomes derived from DLBCL cells were cocultured with T lymphocytes or injected into tumor xenograft mice by tail vein injection. The relationship between the protein expression level of exosomal PD‑L1 in the plasma and the clinical characteristics and immune microenvironmental parameters of GDLBCL was evaluated using immunoblotting and immunohistochemistry. High levels of exosomal PD‑L1 were found in the supernatants of cultured DLBCL cells. Exosomes with high levels of PD‑L1 promoted growth of tumors formed by DLBCL cells

Indexed as

ExosomesLymphoma, Large B-Cell, DiffuseStomach NeoplasmsTumor MicroenvironmentAnimalsB7-H1 AntigenHumansImmunosuppressive AgentsLymphoma, Non-HodgkinMiceB7-H1 AntigenCD274 protein, humanImmunosuppressive Agentsexosomesgastric diffuse large B‑cell lymphomaimmune microenvironmentimmunosuppressionPD‑L1

Identifiers

PMID36928140
PMCPMC10073407
OpenAlexW4324058063

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.