Evidence map›Paper›PMID 36927884›Full record

ArticleNeurology2023

Characterization and Prediction of Short-term Outcomes in Memory After Temporal Lobe Resection in Children With Epilepsy.

Navkiranjot Kaur, Amy S Nowacki, Deepak K Lachhwani, Madison M Berl, Marla J Hamberger, Patricia Klaas, William Bingaman, Robyn M Busch

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Seminars in epileptology: Presurgical epilepsy evaluation.Epileptic disorders : international epilepsy journal with videotape · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Navkiranjot KaurFrom the Cleveland Clinic Lerner College of Medicine (N.K., A.S.N., R.M.B.), Case Western Reserve University; Quantitative Health Sciences (A.S.N.), Lerner Research Institute, Cleveland Clinic; Epilepsy Center (D.K.L., W.B., R.M.B.), Neurological Institute, Cleveland Clinic, OH; Division of Pediatric Neuropsychology (M.M.B.), Childrens National Medical Center, Washington, DC; Department of Neurology (M.J.H.), Columbia University Medical Center, New York, NY; and Department of Psychiatry & Psychology (P.K., R.M.B.), and Department of Neurology (P.K., R.M.B.), Neurological Institute, Cleveland Clinic, OH.
Amy S NowackiFrom the Cleveland Clinic Lerner College of Medicine (N.K., A.S.N., R.M.B.), Case Western Reserve University; Quantitative Health Sciences (A.S.N.), Lerner Research Institute, Cleveland Clinic; Epilepsy Center (D.K.L., W.B., R.M.B.), Neurological Institute, Cleveland Clinic, OH; Division of Pediatric Neuropsychology (M.M.B.), Childrens National Medical Center, Washington, DC; Department of Neurology (M.J.H.), Columbia University Medical Center, New York, NY; and Department of Psychiatry & Psychology (P.K., R.M.B.), and Department of Neurology (P.K., R.M.B.), Neurological Institute, Cleveland Clinic, OH.
Deepak K LachhwaniFrom the Cleveland Clinic Lerner College of Medicine (N.K., A.S.N., R.M.B.), Case Western Reserve University; Quantitative Health Sciences (A.S.N.), Lerner Research Institute, Cleveland Clinic; Epilepsy Center (D.K.L., W.B., R.M.B.), Neurological Institute, Cleveland Clinic, OH; Division of Pediatric Neuropsychology (M.M.B.), Childrens National Medical Center, Washington, DC; Department of Neurology (M.J.H.), Columbia University Medical Center, New York, NY; and Department of Psychiatry & Psychology (P.K., R.M.B.), and Department of Neurology (P.K., R.M.B.), Neurological Institute, Cleveland Clinic, OH.
Madison M BerlFrom the Cleveland Clinic Lerner College of Medicine (N.K., A.S.N., R.M.B.), Case Western Reserve University; Quantitative Health Sciences (A.S.N.), Lerner Research Institute, Cleveland Clinic; Epilepsy Center (D.K.L., W.B., R.M.B.), Neurological Institute, Cleveland Clinic, OH; Division of Pediatric Neuropsychology (M.M.B.), Childrens National Medical Center, Washington, DC; Department of Neurology (M.J.H.), Columbia University Medical Center, New York, NY; and Department of Psychiatry & Psychology (P.K., R.M.B.), and Department of Neurology (P.K., R.M.B.), Neurological Institute, Cleveland Clinic, OH.
Marla J HambergerFrom the Cleveland Clinic Lerner College of Medicine (N.K., A.S.N., R.M.B.), Case Western Reserve University; Quantitative Health Sciences (A.S.N.), Lerner Research Institute, Cleveland Clinic; Epilepsy Center (D.K.L., W.B., R.M.B.), Neurological Institute, Cleveland Clinic, OH; Division of Pediatric Neuropsychology (M.M.B.), Childrens National Medical Center, Washington, DC; Department of Neurology (M.J.H.), Columbia University Medical Center, New York, NY; and Department of Psychiatry & Psychology (P.K., R.M.B.), and Department of Neurology (P.K., R.M.B.), Neurological Institute, Cleveland Clinic, OH.
Patricia KlaasFrom the Cleveland Clinic Lerner College of Medicine (N.K., A.S.N., R.M.B.), Case Western Reserve University; Quantitative Health Sciences (A.S.N.), Lerner Research Institute, Cleveland Clinic; Epilepsy Center (D.K.L., W.B., R.M.B.), Neurological Institute, Cleveland Clinic, OH; Division of Pediatric Neuropsychology (M.M.B.), Childrens National Medical Center, Washington, DC; Department of Neurology (M.J.H.), Columbia University Medical Center, New York, NY; and Department of Psychiatry & Psychology (P.K., R.M.B.), and Department of Neurology (P.K., R.M.B.), Neurological Institute, Cleveland Clinic, OH.
William BingamanFrom the Cleveland Clinic Lerner College of Medicine (N.K., A.S.N., R.M.B.), Case Western Reserve University; Quantitative Health Sciences (A.S.N.), Lerner Research Institute, Cleveland Clinic; Epilepsy Center (D.K.L., W.B., R.M.B.), Neurological Institute, Cleveland Clinic, OH; Division of Pediatric Neuropsychology (M.M.B.), Childrens National Medical Center, Washington, DC; Department of Neurology (M.J.H.), Columbia University Medical Center, New York, NY; and Department of Psychiatry & Psychology (P.K., R.M.B.), and Department of Neurology (P.K., R.M.B.), Neurological Institute, Cleveland Clinic, OH.
Robyn M BuschFrom the Cleveland Clinic Lerner College of Medicine (N.K., A.S.N., R.M.B.), Case Western Reserve University; Quantitative Health Sciences (A.S.N.), Lerner Research Institute, Cleveland Clinic; Epilepsy Center (D.K.L., W.B., R.M.B.), Neurological Institute, Cleveland Clinic, OH; Division of Pediatric Neuropsychology (M.M.B.), Childrens National Medical Center, Washington, DC; Department of Neurology (M.J.H.), Columbia University Medical Center, New York, NY; and Department of Psychiatry & Psychology (P.K., R.M.B.), and Department of Neurology (P.K., R.M.B.), Neurological Institute, Cleveland Clinic, OH. buschr@ccf.org.ORCID 0000-0002-5442-4912
Cleveland Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe aim of this study was to characterize short-term outcomes in episodic memory, as assessed by the Children's Memory Scale (CMS), after temporal lobe resection in children with epilepsy using empirical methods for assessing cognitive change (i.e., reliable change indices [RCI] and standardized regression-based change scores [SRB]) and develop and internally validate clinically applicable models to predict postoperative memory decline.

methodsThis retrospective cohort study included children aged 6-16 years who underwent resective epilepsy surgery that included the temporal lobe (temporal only: "temporal" and multilobar: "temporal plus") and who completed preoperative and postoperative neuropsychological assessments including the CMS. Change scores on the CMS delayed memory subtests (Faces, Stories, and Word Pairs) were classified as decline, no change, or improvement using epilepsy-specific RCI and SRB. Logistic regression models for predicting postoperative memory decline were developed and internally validated with bootstrapping.

resultsOf the 126 children included, most of them demonstrated either no significant change (54%-69%) or improvement (8%-14%) in memory performance using RCI on individual measures at a median of 7 months after surgery. A subset of children (23%-33%) showed postoperative declines. Change distributions obtained using RCI and SRB were not statistically significantly different from each other. Preoperative memory test score, surgery side, surgery extent, and preoperative full-scale IQ were predictors of memory decline. Prediction models for memory decline included subsets of these variables with bias-corrected concordance statistics ranging from 0.70 to 0.75. The models were well calibrated although slightly overestimated the probability of verbal memory decline in high-risk patients. DISCUSSION: This study used empiric methodology to characterize memory outcome in children after temporal lobe resection. Provided online calculator and nomograms may be used by clinicians to estimate the risk of postoperative memory decline for individual patients before surgery.

Indexed as

EpilepsyEpilepsy, Temporal LobeMemory, EpisodicChildHumansMemory DisordersNeuropsychological TestsPostoperative ComplicationsRetrospective StudiesTemporal Lobe

Identifiers

PMID36927884
PMCPMC10159761
OpenAlexW4327541435

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.