ArticleCardiovascular diabetology2023
Positive association of triglyceride-glucose index with new-onset hypertension among adults: a national cohort study in China.
Article in Cardiovascular diabetology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 4 of them syntheses that pooled it.
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Who cites it
54 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Triglyceride-glucose index and the risk of in-hospital and ICU all-cause mortality: a systematic review and meta-analysis of observational studies.Nutrition & diabetes · 2025Pooled it
- The triglyceride-glucose index is associated with a higher risk of hypertension: evidence from a cross-sectional study of Chinese adults and meta-analysis of epidemiology studies.Frontiers in endocrinology · 2025Pooled it
- Exploring the Association Between Cognitive Decline and Triglyceride-Glucose Index: A Systematic Review and Meta-Analysis.Brain and behavior · 2024Pooled it
- Association between triglyceride-glucose index and hypertension: A systematic review and meta-analysis.Narra J · 2024Pooled it
- Interplay between triglyceride-glucose index and cardiovascular events in hypertensive patients with controlled blood pressure (SBP<140 mmHg): insights from the SPRINT trial.Frontiers in endocrinology · 2025Trial
- Machine learning-based prediction model for predicting the impact of insulin resistance on the risk of ischemic cardiomyopathy.BMC medical informatics and decision making · 2026Article
- Association between triglyceride-glucose index and elevated blood pressure among U.S. adolescents aged 12-17.Pediatric research · 2026Article
- Triglyceride-glucose index, genetic predisposition, and incident depression: a prospective cohort study from the UK Biobank.Psychological medicine · 2026Article
- Joint associations of anthropometric indices and C-reactive protein-triglyceride-glucose index with incident hypertension: a stratified analysis by blood pressure level from the CHARLS, 2011-2020.Cardiovascular diabetology · 2026Article
- Review
- Effect modification by fatty liver in the association between triglyceride-Glucose index and new-onset hypertension: a large health-examination cohort study.Frontiers in endocrinology · 2026Article
- Triglyceride-glucose index as a potential biomarker for predicting retinal vein occlusion.Scientific reports · 2025Article
- Cumulative triglyceride-glucose index and hypertension risk: a longitudinal cohort study.BMC public health · 2025Observational
- Association between triglyceride glucose index trajectory and risk of hypertension in rural residents: a prospective cohort study.Scientific reports · 2025Article
- Association Between Triglyceride-Glucose Index, Blood Pressure Status, and Coronary Heart Disease Risk Among Chinese Adults With Disabilities: 10-Year Disability Health Survey Cohort Study.JMIR public health and surveillance · 2025Article
- Associations of insulin resistance surrogate with resistant hypertension and the severity of hypertension in the chronic kidney disease population.Journal of hypertension · 2025Article
- Association between the stress hyperglycemia ratio and elevated blood pressure among U.S. adolescents aged 12-17.Cardiovascular diabetology · 2025Article
- Protective effect of high-density lipoprotein in infective endocarditis patients after valve surgery.International journal of cardiology. Heart & vasculature · 2025Article
- Associations between triglyceride-glucose index in the early trimester of pregnancy and adverse pregnancy outcomes.BMC pregnancy and childbirth · 2025Article
- Association between dynamic changes in the triglyceride-glucose index and prognosis in patients with acute ST-segment elevation myocardial infarction.Cardiovascular diabetology · 2025Article
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12 authors.
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Abstract
backgroundPrevious studies showed that the triglyceride-glucose (TyG) index was a better predictor of adverse cardiovascular events than triglycerides or fasting blood glucose alone. However, few studies have focused on new-onset hypertension. We aimed to explore the association of TyG index with new-onset hypertension in Chinese adults.
methodsA total of 4,600 participants who underwent at least 2 rounds of visits from 2009 to 2015 in the China Health and Nutrition Survey were enrolled in this study. Our outcome of interest was new-onset hypertension. Multivariate Cox hazard regression models and restricted cubic spline were performed to explore the relationship between TyG index and new-onset hypertension.
resultsThe mean (standard deviation, SD) age of the study population was 48.1 (13.6) years, and 2058 (44.7%) of the participants were men. The mean (SD) TyG index level was 8.6 (0.7). A total of 1,211 (26.3%) participants developed new-onset hypertension during a median (interquartile range) follow-up duration of 6.0 (2.0-6.1) years. The incidences of new-onset hypertension were 18.1%, 25.3%, 28.5%, and 33.4% by quartiles of TyG index [from quartile 1 (Q1) to Q4], respectively. The Cox model showed that high levels of TyG index were significantly associated with increased risk of new-onset hypertension (adjusted hazard ratio [aHR]: 1.29, 95% confidence interval [CI] 1.07-1.55, Q2; aHR, 1.24, 95% CI 1.03-1.49, Q3; aHR, 1.50, 95% CI 1.22-1.84, Q4) compared with Q1. Consistently, as a continuous variable, for every 1.0 increase in TyG index, there was a 17% increase in the risk of new-onset hypertension (aHR, 1.17; 95% CI 1.04-1.31). The associations were consistent in various subgroups and sensitivity analysis. The dose-response curve indicated a positive, linear association between TyG index and the risk of new-onset hypertension.
conclusionsHigh TyG index was significantly associated with an increased risk of new-onset hypertension among Chinese adults. Our findings suggest that maintaining a relatively low level of TyG index might be effective in the primary prevention of hypertension.
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