Evidence map›Paper›PMID 36927614›Full record

ArticleeLife2023

Netrin-1 regulates the balance of synaptic glutamate signaling in the adult ventral tegmental area.

Marcella M Cline, Barbara Juarez, Avery Hunker, Ernesto G Regiarto, Bryan Hariadi, Marta E Soden, Larry S Zweifel

Open access · goldFull text read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Marcella M ClineDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, United States.ORCID 0000-0002-9590-3725
Barbara JuarezDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, United States.
Avery HunkerDepartment of Pharmacology, University of Washington, Seattle, United States.
Ernesto G RegiartoDepartment of Pharmacology, University of Washington, Seattle, United States.
Bryan HariadiDepartment of Pharmacology, University of Washington, Seattle, United States.
Marta E SodenDepartment of Pharmacology, University of Washington, Seattle, United States.
Larry S ZweifelDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, United States.ORCID 0000-0003-3465-5331
University of Washington · US

Funding

TRAINING IN MOLECULAR AND CELLULAR BIOLOGYT32GM007270 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 1985 to 2020
$21.0M
University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI Charles Chavkin · 2019 to 2026
$13.0M
TRAINING IN THE MOLECULAR PHARMACOLOGY OF ABUSED DRUGST32DA007278 · NIDA · UNIVERSITY OF WASHINGTON · PI Susan Marie Ferguson, Paul E. M. Phillips · 1993 to 2026
$9.8M
Phasic Dopamine and Symptom Domains of Mental IllnessR01MH104450 · NIMH · UNIVERSITY OF WASHINGTON · PI LARRY S ZWEIFEL · 2015 to 2026
$5.5M
Isolation of brain reward circuits using peptidergic systemsR01DA044315 · NIDA · UNIVERSITY OF WASHINGTON · PI LARRY S ZWEIFEL · 2018 to 2026
$3.5M
Dopamine circuit regulation of morphine reinforcement across the opioid exposure cycleK99DA054265 · NIDA · UNIVERSITY OF WASHINGTON · PI JUAREZ, BARBARA · 2021 to 2022
$344k
The role of axonal guidance genes in the regulation of dopamine-mediated behaviors and synaptic connectivityF31MH126489 · NIMH · UNIVERSITY OF WASHINGTON · PI CLINE, MARCELLA · 2021 to 2021
$41k
NIDA NIH HHS K99 DA054265NIDA NIH HHS P30 DA048736NIDA NIH HHS R01 DA044315NIDA NIH HHS T32 DA007278NIGMS NIH HHS T32 GM007270NIMH NIH HHS F31 MH126489NIMH NIH HHS R01 MH104450
6 · The paper itself

Abstract

The axonal guidance cue netrin-1 serves a critical role in neural circuit development by promoting growth cone motility, axonal branching, and synaptogenesis. Within the adult mouse brain, expression of the gene encoding (

Indexed as

Glutamic AcidVentral Tegmental AreaAnimalsDopaminergic NeuronsMiceNetrin-1Signal TransductionGlutamic AcidNetrin-1behaviorDopamineelectrophysiologymouseNetrinneuroscienceVTA

Identifiers

PMID36927614
PMCPMC10023152
OpenAlexW4327677045

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read38
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.