Evidence map›Paper›PMID 36927512›Full record

ArticleInfection control and hospital epidemiology2023

Matthew J Ziegler, Emilia J Flores, Mika Epps, Kathleen Hopkins, Laurel Glaser, Nikhil K Mull, David A Pegues

Abstract read
In one paragraph

Article in Infection control and hospital epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Screening and targeted prophylaxis for Clostridioides difficile infection.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2025
    Article
  2. Three stages of laboratory stewardship in improving appropriateAntimicrobial stewardship & healthcare epidemiology : ASHE · 2025
    Article
  3. Emerging Diagnostics inInternational journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matthew J ZieglerDivision of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-5723-3927
Emilia J FloresCenter for Evidence-based Practice, University of Pennsylvania Health System, Philadelphia, Pennsylvania, Pennsylvania.
Mika EppsHospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Kathleen HopkinsHospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Laurel GlaserDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Nikhil K MullCenter for Evidence-based Practice, University of Pennsylvania Health System, Philadelphia, Pennsylvania, Pennsylvania.ORCID 0000-0002-1411-7416
David A PeguesDivision of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-5295-0046

Funding

Impact of early gut microbiome features on risk of neutropenic fever and bloodstream infection in hematologic malignancyK23AI143925 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ZIEGLER, MATTHEW · 2020 to 2024
$975k
NIAID NIH HHS K23 AI143925
6 · The paper itself

Abstract

backgroundOrdering Clostridioides difficile diagnostics without appropriate clinical indications can result in inappropriate antibiotic prescribing and misdiagnosis of hospital onset

methodsWe developed an evidence-based clinical algorithm that defined appropriateness criteria for testing for

resultsUsing mixed-effects Poisson regression, we found that the intervention was associated with a reduction in the incidence rate of both

conclusionsAn evidence-based dynamic order panel, integrated within the electronic medical record, was associated with a reduction in both

Indexed as

Clostridioides difficileClostridium InfectionsCross InfectionAnti-Bacterial AgentsClostridioidesHumansInpatientsLaxativesAnti-Bacterial AgentsLaxatives

Identifiers

PMID36927512
PMCPMC10750561

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.