Evidence map›Paper›PMID 36927461›Full record

ArticleTrials2023

The Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C) for serious mental illness in community mental health part 1: study protocol for a hybrid type 2 effectiveness-implementation cluster-randomized trial.

Laurel D Sarfan, Emma R Agnew, Marlen Diaz, Lu Dong, Krista Fisher, Julia M Spencer, Shayna A Howlett, Rafael Esteva Hache, Catherine A Callaway, Amy M Kilbourne and 2 more

Erratum issued Registry-linked trialOpen access · goldFull text readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04154631 (Implementing and Sustaining a Transdiagnostic Sleep and Circadian Treatment to Improve Severe Mental Illness Outcomes in Community Mental Health Part 1), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04154631 nacompletednot on this map

Implementing and Sustaining a Transdiagnostic Sleep and Circadian Treatment to Improve Severe Mental Illness Outcomes in Community Mental Health Part 1: Implementation

TypeinterventionalSponsorUniversity of California, BerkeleyRan2020 to 2023Enrolled489ConditionsSleep Disorder, Circadian DysregulationArmsStandard Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C), Adapted Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C), Usual Care Delayed Treatment
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Laurel D SarfanDepartment of Psychology, University of California, Berkeley, CA, Berkeley, USA.
Emma R AgnewDepartment of Psychology, University of California, Berkeley, CA, Berkeley, USA.
Marlen DiazDepartment of Psychology, University of California, Berkeley, CA, Berkeley, USA.
Lu DongRAND Corporation, Santa Monica, CA, USA.
Krista FisherDepartment of Psychology, University of California, Berkeley, CA, Berkeley, USA.
Julia M SpencerDepartment of Psychology, University of California, Berkeley, CA, Berkeley, USA.
Shayna A HowlettDepartment of Psychology, University of California, Berkeley, CA, Berkeley, USA.
Rafael Esteva HacheDepartment of Psychology, University of California, Berkeley, CA, Berkeley, USA.
Catherine A CallawayDepartment of Psychology, University of California, Berkeley, CA, Berkeley, USA.
Amy M KilbourneUniversity of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.
Daniel J BuysseDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Allison G HarveyDepartment of Psychology, University of California, Berkeley, CA, Berkeley, USA. aharvey@berkeley.edu.ORCID http://orcid.org/0000-0002-8609-0005
University of California, Berkeley · USRAND Corporation · USUniversity of Michigan · USUniversity of Pittsburgh · US

Funding

Implementing and Sustaining a Transdiagnostic Sleep and Circadian Treatment to Improve Severe Mental Illness Outcomes in Community Mental Health.R01MH120147 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARVEY, ALLISON G · 2019 to 2023
$3.9M
Advancing Sustainability of Evidence-Based Treatments in Community Mental HealthF32MH131284 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI SARFAN, LAUREL D · 2022 to 2024
$76k
NIMH NIH HHS F32 MH131284NIMH NIH HHS R01 MH120147NIMH NIH HHS R01MH120147
6 · The paper itself

Abstract

backgroundSerious mental illness (SMI) can have devastating consequences. Unfortunately, many patients with SMI do not receive evidence-based psychological treatment (EBPTs) in routine practice settings. One barrier is poor "fit" between EBPTs and contexts in which they are implemented. The present study will evaluate implementation and effectiveness outcomes of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C) implemented in community mental health centers (CMHCs). TranS-C was designed to target a range of SMI diagnoses by addressing a probable mechanism and predictor of SMI: sleep and circadian problems. We will investigate whether adapting TranS-C to fit CMHC contexts improves providers' perceptions of fit and patient outcomes.

methodsTranS-C will be implemented in at least ten counties in California, USA (N = 96 providers; N = 576 clients), via facilitation. CMHC sites are cluster-randomized by county to Adapted TranS-C or Standard TranS-C. Within each county, patients are randomized to immediate TranS-C or usual care followed by delayed treatment with TranS-C (UC-DT). Aim 1 will compare TranS-C (combined Adapted and Standard) with UC-DT on improvements in sleep and circadian problems, functional impairment, and psychiatric symptoms. Sleep and circadian problems will also be tested as a mediator between treatment condition (combined TranS-C versus UC-DT) and functional impairment/psychiatric symptoms. Aim 2 will evaluate whether Adapted TranS-C is superior to Standard TranS-C with respect to provider perceptions of fit. Aim 3 will evaluate whether the relation between TranS-C treatment condition (Adapted versus Standard) and patient outcomes is mediated by better provider perceptions of fit in the Adapted condition. Exploratory analyses will (1) compare Adapted versus Standard TranS-C on patient perceptions of credibility/improvement and select PhenX Toolkit outcomes and (2) evaluate possible moderators. DISCUSSION: This trial has the potential to (a) expand support for TranS-C, a promising transdiagnostic treatment delivered to patients with SMI in CMHCs; (b) take steps toward addressing challenges faced by providers in delivering EBPTs (i.e., high caseloads, complex patients, poor fit); and (c) advance evidence on causal strategies (i.e., adapting treatments to fit context) in implementation science.

trial registrationClinicaltrials.gov NCT04154631. Registered on 6 November 2019. https://clinicaltrials.gov/ct2/show/NCT04154631.

Indexed as

Mental DisordersMental HealthHumansImplementation ScienceRandomized Controlled Trials as TopicSleepAdaptationCircadianCommunity mental healthImplementationSerious mental illnessSleepTransdiagnostic

Identifiers

PMID36927461
PMCPMC10020076
OpenAlexW4327680000

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read11
identifiers read2
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.