Trial reportJournal of cardiothoracic surgery2023
Low-dose versus standard-dose computed tomography-guided biopsy for pulmonary nodules: a randomized controlled trial.
Trial report in Journal of cardiothoracic surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04217655 (Low-dose Computed Tomography-guided Core Needle Biopsy for Lung Nodules), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Low-dose Computed Tomography-guided Core Needle Biopsy for Lung Nodules
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The value of chest CT in the differential diagnosis of benign and malignant pulmonary nodules: a meta-analysis.Frontiers in medicine · 2026Pooled it
- A systematic review and meta-analysis of randomized controlled trials comparing low-dose versus standard-dose computed tomography-guided lung biopsy.Journal of cardiothoracic surgery · 2024Pooled it
- Preoperative computed tomography-guided localization of pulmonary nodules: comparison between tailed coil and suture anchor localization.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2026Article
- Cutting doses, keeping diagnoses: outcomes of protocol optimization for CT-guided lung biopsies.La Radiologia medica · 2026Article
- Comparing the effectiveness and safety of robotic-assisted bronchoscopy and computed tomography-guided transthoracic biopsy for evaluating pulmonary lung nodules: results from the DYSTRICT study.ERJ open research · 2026Article
- Computed tomography-guided biopsy for pulmonary nodules: comparison between with and without coaxial technique.Journal of cardiothoracic surgery · 2026Article
- Uncertainty-Aware Framework for CT Radiation Dose Optimization in the Active Surveillance of Small Renal Masses: Clinical and Radiological Considerations.Diagnostics (Basel, Switzerland) · 2026Article
- Development and validation of the Pulmonary Nodule Malignant Transformation Fear Scale (PN-MTFS) to identify patients at high risk of cancer-related fear: a multicenter study.Frontiers in psychology · 2026Article
- Safety and diagnostic accuracy of image-guided transthoracic core needle biopsy in pediatric patients.Polish journal of radiology · 2026Article
- Use of a soft guiding template and laser device improves the success rate of computed tomography-guided bone biopsies and reduces radiation exposure.BMC medical imaging · 2025Article
- Comparison of computed tomography-guided core needle biopsy of pulmonary nodules performed with and without the coaxial technique.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2024Article
- Patient-reported respiratory symptoms and relevant factors in patients with pulmonary nodules.Journal of thoracic disease · 2024Article
- Non-malignant pathological results from CT-guided biopsy for pulmonary nodules: a predictive model for identifying false-negative results.Journal of cardiothoracic surgery · 2024Article
- Ultrasound versus computed tomography guided percutaneous needle biopsy for subpleural pulmonary lesions.Frontiers in oncology · 2024Article
- Comparison of indocyanine green and blue-stained glue for preoperative localization for pulmonary nodules.Frontiers in oncology · 2024Article
- Systematic review and meta-analysis of low-dose CT-driven biopsy for pulmonary nodules.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2023Article
- Computed tomography-guided biopsy for sub-centimetre pulmonary nodules: a meta-analysis.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo assess relative safety and diagnostic performance of low- and standard-dose computed tomography (CT)-guided biopsy for pulmonary nodules (PNs). MATERIALS AND
methodsThis was a single-center prospective randomized controlled trial (RCT). From June 2020 to December 2020, consecutive patients with PNs were randomly assigned into low- or standard-dose groups. The primary outcome was diagnosis accuracy. The secondary outcomes included technical success, diagnostic yield, operation time, radiation dose, and biopsy-related complications. This RCT was registered on 3 January 2020 and listed within ClinicalTrials.gov (NCT04217655).
resultsTwo hundred patients were randomly assigned to low-dose (n = 100) and standard-dose (n = 100) groups. All patients achieved the technical success of CT-guided biopsy and definite final diagnoses. No significant difference was found in operation time (n = 0.231) between the two groups. The mean dose-length product was markedly reduced within the low-dose group compared to the standard-dose group (31.5 vs. 333.5 mGy-cm, P < 0.001). The diagnostic yield, sensitivity, specificity, and accuracy of the low-dose group were 68%, 91.5%, 100%, and 94%, respectively. The diagnostic yield, sensitivity, specificity, and accuracy were 65%, 88.6%, 100%, and 92% in the standard-dose group. There was no significant difference observed in diagnostic yield (P = 0.653), diagnostic accuracy (P = 0.579), rates of pneumothorax (P = 0.836), and lung hemorrhage (P = 0.744) between the two groups.
conclusionsCompared with standard-dose CT-guided biopsy for PNs, low-dose CT can significantly reduce the radiation dose, while yielding comparable safety and diagnostic accuracy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.