Evidence map›Paper›PMID 36927391›Full record

ArticleGut microbes

GPR120 promotes neutrophil control of intestinal bacterial infection.

Zheng Zhou, Wenjing Yang, Tianming Yu, Yu Yu, Xiaojing Zhao, Yanbo Yu, Chuncai Gu, Anthony J Bilotta, Suxia Yao, Qihong Zhao and 3 more

Erratum issuedOpen access · goldFull text read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Dysregulated immunometabolism in gut inflammation.Acta biochimica et biophysica Sinica · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Rhein againstCurrent research in food science · 2024
    Article
  10. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Zheng ZhouDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, USA.
Wenjing YangDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, USA.
Tianming YuDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, USA.
Yu YuDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, USA.
Xiaojing ZhaoDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, USA.
Yanbo YuDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, USA.
Chuncai GuDepartment of Gastroenterology, Nan Fang Hospital, Southern Medical University, Guangzhou, China.
Anthony J BilottaDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, USA.
Suxia YaoDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, USA.
Qihong ZhaoBristol-MyersSquibb, Princeton, New Jersey, USA.
George GolovkoDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, USA.
Mingsong LiDepartment of Gastroenterology, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yingzi CongDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, USA.ORCID 0000-0003-4167-7395
The University of Texas Medical Branch at Galveston · USThird Affiliated Hospital of Guangzhou Medical University · CNBristol-Myers Squibb (United States) · USSouthern Medical University · CN

Funding

STING signaling in T cells regulation of intestinal homeostasis and inflammatorybowel diseasesR01DK124132 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CONG, YINGZI · 2020 to 2024
$2.5M
GPR120 regulation of inflammatory bowel diseaseR01DK125011 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CONG, YINGZI · 2020 to 2022
$1.5M
Microbiota metabolites, GPR, and inflammatory bowel diseasesR01DK112436 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CONG, YINGZI · 2017 to 2020
$1.4M
GPR120 regulation of intestinal IgA responses and gut IgA-coated bacteriaR21AI150210 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SUN, JIAREN · 2020 to 2021
$435k
NIAID NIH HHS R21 AI150210NIDDK NIH HHS R01 DK112436NIDDK NIH HHS R01 DK124132NIDDK NIH HHS R01 DK125011
6 · The paper itself

Abstract

G-protein coupled receptor 120 (GPR 120) has been implicated in anti-inflammatory functions. However, how GPR120 regulates the neutrophil function remains unknown. This study investigated the role of GPR120 in the regulation of neutrophil function against enteric bacteria. 16S rRNA sequencing was used for measuring the gut microbiota of wild-type (WT) mice and

Indexed as

Enterobacteriaceae InfectionsGastrointestinal MicrobiomeAnimalsBacteriaEscherichia coliMiceNeutrophilsReactive Oxygen SpeciesRNA, Ribosomal, 16SReactive Oxygen SpeciesRNA, Ribosomal, 16SGPR120gut microbiotaInteric infectionIntestinal inflammationNeutrophil

Identifiers

PMID36927391
PMCPMC10026904
OpenAlexW4327681954

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read61
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.