Evidence map›Paper›PMID 36927287›Full record

SynthesisGut microbes

A systematic review of associations between gut microbiota composition and growth failure in preterm neonates.

Larissa L Neves, Amy B Hair, Geoffrey A Preidis

Open access · goldFull text readSystematic Review
In one paragraph

Synthesis in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Article
  6. [A prospective cohort study of gut microbiota changes in very preterm infants with bronchopulmonary dysplasia].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Preterm growth assessment: the latest findings on age correction.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  11. The impact of gut microbiota on morbidities in preterm infants.The Kaohsiung journal of medical sciences · 2024
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Larissa L NevesDivision of Gastroenterology, Hepatology, & Nutrition, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
Amy B HairDivision of Neonatology, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
Geoffrey A PreidisDivision of Gastroenterology, Hepatology, & Nutrition, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.ORCID 0000-0002-2206-6452
Baylor College of Medicine · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3M
The Clinical Translational Research Certificate of Added Qualification ProgramT32GM136554 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI Melissa Suter, IGNATIA B VAN DEN VEYVER · 2020 to 2026
$3.0M
Non-invasive analysis of methylated cell free DNA in necrotizing enterocolitisR01DK124614 · NIDDK · WASHINGTON UNIVERSITY · PI GOOD, MISTY L, PETERS, DAVID GERARD · 2021 to 2024
$2.5M
Nuclear receptor mediated bile acid alterations and coagulopathy in protein-energy undernutritionK08DK113114 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI PREIDIS, GEOFFREY A · 2017 to 2021
$815k
NIDDK NIH HHS K08 DK113114NIDDK NIH HHS P30 DK056338NIDDK NIH HHS R01 DK124614NIGMS NIH HHS T32 GM136554
6 · The paper itself

Abstract

Growth failure is among the most prevalent and devastating consequences of prematurity. Up to half of all extremely preterm neonates struggle to grow despite modern nutrition practices. Although elegant preclinical models suggest causal roles for the gut microbiome, these insights have not yet translated into biomarkers that identify at-risk neonates or therapies that prevent or treat growth failure. This systematic review aims to identify features of the neonatal gut microbiota that are positively or negatively associated with early postnatal growth. We identified 860 articles, of which 14 were eligible for inclusion. No two studies used the same definitions of growth, ages at stool collection, and statistical methods linking microbiota to metadata. In all, 58 different taxa were associated with growth, with little consensus among studies. Two or more studies reported positive associations with Enterobacteriaceae,

Indexed as

Gastrointestinal MicrobiomeMicrobiotaEnterobacteriaceaeFecesHumansInfantInfant, NewbornInfant, PrematureGrowth failuregut microbiomemalnutritionneonatepostnatal growthpreterm infantunderweight

Identifiers

PMID36927287
PMCPMC10026866
OpenAlexW4327590138

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read47
identifiers read1
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.