Evidence map›Paper›PMID 36927215›Full record

ArticleDrug delivery2023

Gadolinium-based MR cisternography with prepontine cisternal routine for evaluating distribution pattern of intrathecal targeted drug delivery in pain management.

Haocheng Zhou, Dingquan Zou, Bo Hong, Rong Hu, Tongbiao Yang, Xinning Li, Xin Li, Junjiao Hu, Ruixuan Wang, Yaping Wang

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Technical guideline for intra-prepontine cisternal drug delivery via spinal puncture through subarachnoid catheterization.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Guideline
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Haocheng ZhouDepartment of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, China.
Dingquan ZouDepartment of Pain Management and Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Bo HongDepartment of Pain Management and Anesthesiology, Yueyang Traditional Chinese Medicine Hospital, Yueyang, China.
Rong HuDepartment of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, China.
Tongbiao YangDepartment of Pain, Yongzhou Central Hospital, Yongzhou, China.
Xinning LiDepartment of Pain Management and Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Xin LiDepartment of Pain Management and Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Junjiao HuDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Ruixuan WangBourns Engineering, The University of California, Riverside, Riverside, California, USA.
Yaping WangDepartment of Pain Management and Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNSecond Xiangya Hospital of Central South University · CNThird Xiangya Hospital · CNUniversity of California, Riverside · USYueyang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gadolinium-based MR cisternography has been mainly applied in clinical evaluation of cerebrospinal fluid leaking, that is conducted by intrathecal administration of contrast media. Recently, we have reported one novel technique of intrathecal targeted drug delivery with prepontine cisternal routine to treat orofacial cancer pain. The aim of this study was to examine the distribution pattern of this intrathecal drug delivery strategy. Here, we introduce one case who suffered severe orofacial pain caused by sublingual gland tumor, and successfully attenuated by prepontine cisternal administration of analgesic agents. To assess the distribution of intrathecal drugs, postoperative MR images of brain, cervical, thoracic, and lumbar segments in axial, coronal, and sagittal planes were obtained after application of gadolinium. The perfusion rate of contrast medium was set at 0.01 mmol per hour for 24 hours prior to MR scanning. In the T1-weighted images, we can identify contrast spread not only locating around the site of the intrathecal catheter tip, but also concentrated to the lateral sides. None obvious side effect was found after intrathecal injection of contrast media. Thus, our finding demonstrated the local distribution phenomenon of intrathecal drugs through prepontine cisternal access, and the bilateral perfusion pattern may provide insights underlying the analgesic mechanism of trigeminal pain provided by this novel intrathecal therapy. Gadolinium-based MR cisternography may serve as a potential tool to confirm the therapeutic effect of intrathecal targeted drug delivery via prepontine cisternal routine in orofacial pain management.

Indexed as

Contrast MediaGadoliniumGadolinium DTPAHumansMagnetic Resonance ImagingPainPain ManagementContrast MediaGadoliniumGadolinium DTPAcisternographydistributionGadoliniumintrathecal targeted drug deliveryprepontine cisternal

Identifiers

PMID36927215
PMCPMC10026817
OpenAlexW4327680985

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read12
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.