ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2023
Reduced coupling of global brain function and cerebrospinal fluid dynamics in Parkinson's disease.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 44 citations in OpenAlex.
- Transcranial direct current stimulation improves reduced global BOLD-CSF coupling in patients with insomnia disorder and comorbid anxiety: a resting-state functional MRI study.BMC psychiatry · 2026Trial
- Modifiable Physiological Factors Associated With Human Glymphatic and Interstitial Fluid Dynamics-Related Measures: A Scoping Review.The European journal of neuroscience · 2026Article
- The Glymphatic System in α-Synucleinopathies.Yonsei medical journal · 2026Review
- Task-Evoked Functional Activation and Coupling With CSF Flow Detected in the Human Brain With Ultrashort Echo Time fMRI at 7 T.NMR in biomedicine · 2026Article
- Association of glymphatic function with 40-Hz neural oscillations, systemic metabolic markers, and cognitive performance in healthy aging adults: An EEG and MRI study.Translational psychiatry · 2026Article
- Impaired glymphatic function and advanced brain age gap in chronic migraine: a multimodal MRI study.The journal of headache and pain · 2026Article
- Myasthenia Gravis patients have reduced DTI-ALPS-Index and gBOLD-CSF coupling, suggesting impaired brain waste clearance.Brain imaging and behavior · 2026Article
- Association of the along‑perivascular space (ALPS) index and white matter volume with cognitive dysfunction in relapsing‑remitting multiple sclerosis patients.BMC neurology · 2026Article
- Network-specific enhancement of global blood-oxygen-level-dependent signals and CSF coupling after language therapy in post-stroke aphasia.Brain communications · 2026Article
- Reduced BOLD-CSF coupling as a potential functional imaging correlate of semantic fluency decline in MRI-negative temporal lobe epilepsy.Frontiers in aging neuroscience · 2026Article
- Neuroimaging and Transcriptomic Insights Into Iron Accumulation and Glymphatic Dysfunction in Olfactory Dysfunction.CNS neuroscience & therapeutics · 2026Article
- The glymphatic system in neurodegenerative diseases and brain tumors: mechanistic insights, biomarker advances, and therapeutic opportunities.Acta neuropathologica communications · 2025Review
- MRI-based surrogates of brain clearance in narcolepsy type 1.Journal of sleep research · 2025Article
- Clearance mechanisms of the glymphatic/lymphatic system in the brain: new therapeutic perspectives for cognitive impairment.Cognitive neurodynamics · 2025Review
- The influence of intermittent hypercapnia on cerebrospinal fluid flow and clearance in Parkinson's disease and healthy older adults.NPJ Parkinson's disease · 2025Article
- Glymphatic System Dysfunction in Thyroid-Associated Ophthalmopathy: A Multimodal MRI Study.CNS neuroscience & therapeutics · 2025Article
- Reduced glymphatic clearance in early psychosis.Molecular psychiatry · 2025Article
- The coupling of global brain activity and cerebrospinal fluid flow as a potential predictive marker of brain amyloid-β accumulation.The journal of prevention of Alzheimer's disease · 2025Observational
- Temporal fluctuation in lateral ventricle volume and its coupling with CSF inflow and global BOLD signal.Scientific reports · 2025Article
- Alterations in the Glymphatic System and Association with Brain Structure and Cognitive Function in Moyamoya Disease.Translational stroke research · 2025Article
Corrections and comments
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Authors and funding
17 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dysfunction of the glymphatic system, an intracranial clearance pathway that drains misfolded proteins, has been implicated in the onset of Parkinson's disease (PD). Recently, the coupling strength of global blood-oxygen-level-dependent (gBOLD) signals and cerebrospinal fluid (CSF) inflow dynamics have been suggested to be an indicator of glymphatic function. Using resting-state functional magnetic resonance imaging (MRI), we quantified gBOLD-CSF coupling strength as the cross-correlation between baseline gBOLD and CSF inflow signals to evaluate glymphatic function and its association with the clinical manifestations of PD. We found that gBOLD-CSF coupling in drug-naïve PD patients was significantly weaker than that in normal controls, but significantly stronger in patients less affected by sleep disturbances than in those more affected by sleep disturbances, based on the PD sleep scale. Furthermore, we collected longitudinal data from patients and found that baseline gBOLD-CSF coupling negatively correlated with the rate of change over time, but positively correlated with the rate of change in UPDRS-III scores. In conclusion, severe gBOLD-CSF decoupling in PD patients may reflect longitudinal motor impairment, thereby providing a potential marker of glymphatic dysfunction in PD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.