Evidence map›Paper›PMID 36927038›Full record

ArticleHuman gene therapy2023

Michelle Mendiola Pla, Yuting Chiang, Antonio Roki, Chunbo Wang, Franklin H Lee, Matthew F Smith, Ryan T Gross, Jun-Neng Roan, Muath Bishawi, Amy Evans and 7 more

Open access · greenAbstract read
In one paragraph

Article in Human gene therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. AAV vector development, back to the future.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  5. Review
  6. Delivery of a Muscle-Targeted Adeno-Associated Vector ViaTransplant international : official journal of the European Society for Organ Transplantation · 2025
    Article
  7. A porcine model of acute rejection for cardiac transplantation.Frontiers in cardiovascular medicine · 2025
    Article
  8. Cardiac preservation usingFrontiers in cardiovascular medicine · 2025
    Article
  9. Human gene therapy · 2024
    Review
  10. Current RNA strategies in treating cardiovascular diseases.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Review
  11. Machine Perfusion and Bioengineering Strategies in Transplantation-Beyond the Emerging Concepts.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
  12. Article
  13. Article
  14. Review
  15. Gene therapy duringFrontiers in cardiovascular medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Michelle Mendiola PlaDivision of Cardiothoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Yuting ChiangDivision of Cardiothoracic Surgery, Department of Surgery, Columbia University Medical Center, New York City, New York, USA.
Antonio RokiDivision of Surgical Sciences, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Chunbo WangDivision of Surgical Sciences, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Franklin H LeeDivision of Surgical Sciences, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Matthew F SmithDivision of Surgical Sciences, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Ryan T GrossDivision of Surgical Sciences, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Jun-Neng RoanDivision of Cardiovascular Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Muath BishawiDivision of Cardiothoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Amy EvansPerfusion Services, Duke University Medical Center, Durham, North Carolina, USA.
Lynden E GaultGift of Hope Organ and Tissue Donor Network, Itasca, Illinois, USA.
Sam HoGift of Hope Organ and Tissue Donor Network, Itasca, Illinois, USA.
Carolyn GlassDepartment of Pathology, Duke University Medical Center, Durham, North Carolina, USA.
Jacob N SchroderDivision of Cardiothoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Paul LezbergTransMedics, Inc., Andover, Massachusetts, USA.
Carmelo A MilanoDivision of Cardiothoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Dawn E BowlesDivision of Surgical Sciences, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Duke Medical Center · USGift of Hope Organ and Tissue Donor Network · USAndover Eye Associates · USColumbia University Irving Medical Center · USDuke University · USNational Cheng Kung University Hospital · TW

Funding

MULTIDISCIPLINARY HEART &VASCULAR DISEASEST32HL007101 · NHLBI · DUKE UNIVERSITY · PI FREEDMAN, NEIL J. · 1985 to 2020
$9.8M
NHLBI NIH HHS T32 HL007101
6 · The paper itself

Abstract

Transplantation, the gold standard intervention for organ failure, is a clinical field that is ripe for applications of gene therapy. One of the major challenges in applying gene therapy to this field is the need for a method that achieves consistent and robust gene delivery to allografts. Normothermic

Indexed as

Heart TransplantationAllograftsAnimalsGenetic TherapyHumansPerfusionSwineTissue Donorsadeno-associated virusex vivo machine perfusiongene deliverygene therapytransplantationviral vectors

Identifiers

PMID36927038
PMCPMC10325812
OpenAlexW4327675675

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.