ArticleACS infectious diseases2023
Soft QPCs: Biscationic Quaternary Phosphonium Compounds as Soft Antimicrobial Agents.
Article in ACS infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Phosphonium-based disinfectants are as effective as best-in-class quaternary ammonium compounds in the eradication of established biofilms in antibiotic-resistant bacteria.Microbiology spectrum · 2026Article
- Hydroxylated Alkyl and Phenyl Phosphonium Ionic Liquids Exhibit Enhanced Antibacterial and Anti-Biofilm Activity.Antibiotics (Basel, Switzerland) · 2026Article
- Mechanism and Molecular Design Principles of Cationic Surfactants: From Charge-Driven Membrane Interactions to Next-Generation Quaternary Ammonium Compounds.ChemMedChem · 2026Review
- Structure-Function Insights into Quinuclidine-3-One BisQACs: Synthesis, Modulation of Bacterial Resistance, Structure-Activity Relationship, and Biological Profiling.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Bisphosphonium Amphiphiles Yield Insights into Gram-Negative Bacterial Disinfectant Resistance and Cell Membrane Interactions.ACS omega · 2025Article
- From Natural Products to Small Molecules: Recent Advancements in Anti-MRSA Therapeutics.ACS medicinal chemistry letters · 2025Review
- Not all disinfectants are created equal: the importance of mechanistic understanding to drive research forward.Future microbiology · 2025Article
- Bushy-Tailed Multicationic Quaternary Phosphonium Compounds: Potent Amphiphilic Disinfectants with Promising Therapeutic Indices.ChemMedChem · 2025Article
- The Slow Pandemic: Emergence of Antimicrobial Resistance in the Postadvent of SARS-CoV-2 Pandemic.Global health, epidemiology and genomics · 2025Review
- Highly Effective Biocides againstACS infectious diseases · 2024Article
- Naturally derived 3-aminoquinuclidine salts as new promising therapeutic agents.Scientific reports · 2024Article
- Chimeric Amphiphilic Disinfectants: Quaternary Ammonium/Quaternary Phosphonium Hybrid Structures.ChemMedChem · 2024Article
- The key phosphorus moieties in drug design: antimicrobials and beyond.Future medicinal chemistry · 2024Article
- Multiheaded Cationic Surfactants with Dedicated Functionalities: Design, Synthetic Strategies, Self-Assembly and Performance.Molecules (Basel, Switzerland) · 2023Review
- Further Study of the Polar Group's Influence on the Antibacterial Activity of the 3-Substituted Quinuclidine Salts with Long Alkyl Chains.Antibiotics (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Quaternary ammonium compounds (QACs) serve as a first line of defense against infectious pathogens. As resistance to QACs emerges in the environment, the development of next-generation disinfectants is of utmost priority for human health. Balancing antibacterial potency with environmental considerations is required to effectively counter the development of bacterial resistance. To address this challenge, a series of 14 novel biscationic quaternary phosphonium compounds (bisQPCs) have been prepared as amphiphilic disinfectants through straightforward, high-yielding alkylation reactions. These compounds feature decomposable or "soft" amide moieties in their side chains, anticipated to promote decomposition under environmental conditions. Strong bioactivity against a panel of seven bacterial pathogens was observed, highlighted by single-digit micromolar activity for compounds P6P-12A,12A and P3P-12A,12A. Hydrolysis experiments in pure water and in buffers of varying pH revealed surprising decomposition of the soft QPCs under basic conditions at the phosphonium center, leading to inactive phosphine oxide products; QPC stability (>24 h) was maintained in neutral solutions. The results of this work unveil soft QPCs as a potent and environmentally conscious new class of bisQPC disinfectants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.