ArticleNeural regeneration research2023
Age-related hearing loss accelerates the decline in fast speech comprehension and the decompensation of cortical network connections.
Article in Neural regeneration research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The Temporal Resolution Needed for Speech Intelligibility Assessed with Mosaic Speech: Effects of Block Duration, Age, and Word Familiarity.Audiology research · 2026Article
- Auditory Biomarkers in Neurodegenerative Disorders: A Literature Review.Journal of otology · 2026Review
- Disrupted structural covariance network in presbycusis patients: evidence from a large sample mri-based morphometric study.Frontiers in aging neuroscience · 2026Article
- Advances in pathogenesis, novel therapeutic strategies and interventions for age-related hearing loss.Frontiers in molecular neuroscience · 2026Review
- Resting-state EEG microstate dynamics indicate altered brain network temporal organization in age-related hearing loss.Frontiers in aging neuroscience · 2026Article
- Neural frequency-tagging of syllables in naturalistic speech is sensitive to background noise and age-related hearing loss.Frontiers in aging neuroscience · 2026Article
- [Analyzing the factors influencing speech recognition ability in patients with age-related hearing loss].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025Article
- Impact of age-related hearing loss on decompensation of left DLPFC during speech perception in noise: a combined EEG-fNIRS study.GeroScience · 2025Article
- When age tips the balance: A dual mechanism affecting hemispheric specialization for language.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Joint Aging Patterns in Brain Function and Structure Revealed Using 27,793 Samples.Research (Washington, D.C.) · 2025Article
- Article
- Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation.Brain : a journal of neurology · 2024Article
- When Age Tips the Balance: a Dual Mechanism Affecting Hemispheric Specialization for Language.bioRxiv : the preprint server for biology · 2023Article
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13 authors.
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Abstract
Patients with age-related hearing loss face hearing difficulties in daily life. The causes of age-related hearing loss are complex and include changes in peripheral hearing, central processing, and cognitive-related abilities. Furthermore, the factors by which aging relates to hearing loss via changes in auditory processing ability are still unclear. In this cross-sectional study, we evaluated 27 older adults (over 60 years old) with age-related hearing loss, 21 older adults (over 60 years old) with normal hearing, and 30 younger subjects (18-30 years old) with normal hearing. We used the outcome of the upper-threshold test, including the time-compressed threshold and the speech recognition threshold in noisy conditions, as a behavioral indicator of auditory processing ability. We also used electroencephalography to identify presbycusis-related abnormalities in the brain while the participants were in a spontaneous resting state. The time-compressed threshold and speech recognition threshold data indicated significant differences among the groups. In patients with age-related hearing loss, information masking (babble noise) had a greater effect than energy masking (speech-shaped noise) on processing difficulties. In terms of resting-state electroencephalography signals, we observed enhanced frontal lobe (Brodmann's area, BA11) activation in the older adults with normal hearing compared with the younger participants with normal hearing, and greater activation in the parietal (BA7) and occipital (BA19) lobes in the individuals with age-related hearing loss compared with the younger adults. Our functional connection analysis suggested that compared with younger people, the older adults with normal hearing exhibited enhanced connections among networks, including the default mode network, sensorimotor network, cingulo-opercular network, occipital network, and frontoparietal network. These results suggest that both normal aging and the development of age-related hearing loss have a negative effect on advanced auditory processing capabilities and that hearing loss accelerates the decline in speech comprehension, especially in speech competition situations. Older adults with normal hearing may have increased compensatory attentional resource recruitment represented by the top-down active listening mechanism, while those with age-related hearing loss exhibit decompensation of network connections involving multisensory integration.
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