Evidence map›Paper›PMID 36926614›Full record

ArticleJournal of ginseng research2023

Longevity, tumor, and physical vitality in rats consuming ginsenoside Rg1.

Chao-Chieh Hsieh, Chiung-Yun Chang, Tania Xu Yar Lee, Jinfu Wu, Suchada Saovieng, Yu-Wen Hsieh, Maijian Zhu, Chih-Yang Huang, Chia-Hua Kuo

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Article in Journal of ginseng research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Enhanced Anti-Lung Cancer Effects of SteamedInternational journal of molecular sciences · 2025
    Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chao-Chieh HsiehLaboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.
Chiung-Yun ChangLaboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.
Tania Xu Yar LeeLaboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.
Jinfu WuLaboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.
Suchada SaoviengLaboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.
Yu-Wen HsiehLaboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.
Maijian ZhuLaboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.
Chih-Yang HuangCardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Chia-Hua KuoLaboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Effects of the major ginsenoside Rg1 on mammalian longevity and physical vitality are rarely reported. Purpose: To examine longevity, tumor, and spontaneous locomotor activity in rats consuming Rg1. Methods: A total of 138 Wistar rats were randomized into 2 groups: control (N = 69) and Rg1 (N = 69). Rg1 (0.1 mg/kg per day) were orally supplemented from 6 months of age until natural death. Spontaneous mobility was measured by video-tracking together with body composition (dual energy x-ray absorptiometry) and inflammation markers at 5, 14, 21, and 28 months of age. Results: No significant differences in longevity (control: 706 days; Rg1: 651 days, Conclusion: The results of the study suggest a delay age-dependent decline in physical vitality during late life by lifelong Rg1 consumption. This improvement is associated with inflammatory modulation. Significant effects of Rg1 on longevity and tumorigenesis were not observed.

Indexed as

Dual-energy x-ray absorptiometry, (DEXA)GinsengHigh-fructose corn syrup, (HFCS)IL-10InflammationInstitutional Animal Care and Use Committee, (IACUC)Interleukin-10, (IL-10)Muscle massObesityOxidized LDLOxidized low density lipoprotein, (oxidized LDL)Standard error, (SE)TNF-αTumor necrosis factor-α, (TNF-α)Two-way analysis of variance, (ANOVA)

Identifiers

PMID36926614
PMCPMC10014179

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.