ReviewCurrent research in microbial sciences2023
Effect of charge on the antimicrobial activity of alpha-helical amphibian antimicrobial peptide.
Review in Current research in microbial sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Recent Progress in Antimicrobial Peptides (AMPs) Towards Enhanced Selectivity and Reduced Cytotoxicity by Molecular Engineering.Biotechnology and bioengineering · 2026Review
- PecbloodinApplied and environmental microbiology · 2026Article
- Article
- Hybrid and conjugated antimicrobial peptides: new tactics to counter bacterial resistance.Frontiers in microbiology · 2026Review
- Design, Structural Stability, Membrane Binding, and Antibacterial Activity of Novel Antimicrobial Peptides Derived from Wuchuanin-A1.Life (Basel, Switzerland) · 2025Article
- Electrostatic Targeting of Cancer Cell Membrane Models by NA-CATH:ATRA-1-ATRA-1: A Biophysical Perspective.Membranes · 2025Article
- Production, Delivery, and Regulatory Aspects for Application of Plant-Based Anti-microbial Peptides: a Comprehensive Review.Probiotics and antimicrobial proteins · 2025Review
- Frog Skin Peptides Hylin-a1, AR-23, and RV-23: Promising Tools Against Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2025Article
- Engineered Lysin-Derived Peptide as a Potent Antimicrobial for Acne Vulgaris.Antibiotics (Basel, Switzerland) · 2025Article
- Protease-Resistant, Broad-Spectrum Antimicrobial Peptides with High Antibacterial and Antifungal Activity.Life (Basel, Switzerland) · 2025Article
- The effect of C-terminal deamidation on bacterial susceptibility and resistance to modelin-5.European biophysics journal : EBJ · 2025Article
- Engineering of antimicrobial peptide Brevinin-1pl: arginine, lysine, and histidine substitutions enhance antimicrobial-anticancer efficacy with reduced cytotoxicity.Frontiers in chemistry · 2025Article
- A Critical Review of Short Antimicrobial Peptides from Scorpion Venoms, Their Physicochemical Attributes, and Potential for the Development of New Drugs.The Journal of membrane biology · 2024Review
- The Effects of Different Antimicrobial Peptides (A-11 and AP19) on Isolated Bacteria from Fresh Boar Semen and Semen Quality during Storage at 18 °C.Antibiotics (Basel, Switzerland) · 2024Article
- The Effect of Antimicrobial Peptide (PA-13) onAntibiotics (Basel, Switzerland) · 2024Article
- Analysis of engineered T7 bacteriophages containing genetic sequences encoding antimicrobial peptides.Frontiers in antibiotics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotic resistance is a severe threat to the world's public health, which has increased the need to discover novel antibacterial molecules. In this context, an emerging class of naturally occurring short peptide molecules called antimicrobial peptides (AMPs) has been considered potent antibacterial agents. Amphibians are one of the significant sources of AMPs, which have been extensively studied for the last few decades. Most amphibian AMPs are cationic, and several of these cationic AMPs adopt a well-defined alpha-helical structure in the presence of bacterial membranes. These cationic alpha-helical amphibian AMPs (CαAMPs) can selectively and preferentially bind with the negatively charged surfaces of Gram-positive and Gram-negative bacteria through electrostatic interaction, considered the main reason for their antibacterial activities. Here, we categorized these CαAMPs according to their charge, and to calculate the charge density; we divided the charge of each peptide by its corresponding length. To investigate the effect of charge among these categories, charge or charge density under each charge category was plotted against their corresponding minimum inhibitory concentration (MIC). Moreover, the effect of charge modification of some CαAMPs under specific charge categories in the context of MIC and hemolysis was also discussed. The information in this review will help us understand the antibacterial activity of accessible CαAMPs depending on each charge category across species. Additionally, this study suggests that designing novel functional antibacterial agents requires charge modification optimally.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.