ArticleFrontiers in network physiology2022
Global and non-Global slow oscillations differentiate in their depth profiles.
Article in Frontiers in network physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 7 citations in OpenAlex.
- Sleep slow oscillation emergence on the scalp as a renewal point process.PLoS computational biology · 2026Article
- Slow wave canonical activity deviation concept: Toward a slow wave-based EEG-fMRI reference map for health-associated network function.iScience · 2026Article
- Classifying Sleep Slow Oscillations in Low Density EEG.Neuroinformatics · 2026Article
- Differences in sleep spindles and polysomnography in humans: a meta-analysis on the influence of age, sex, and cognitive ability.Frontiers in sleep · 2026Review
- A user's introduction to an algorithmic method to identify space-time profiles of sleep slow oscillations: dataset constraints, case-use examples, and open-source code.Sleep advances : a journal of the Sleep Research Society · 2026Article
- The Space-Time Organisation of Sleep Slow Oscillations as Potential Biomarker for Hypersomnolence.Journal of sleep research · 2025Article
- A classification-based generative approach to selective targeting of global slow oscillations during sleep.Frontiers in human neuroscience · 2024Article
- From macro to micro: slow-wave sleep and its pivotal health implications.Frontiers in sleep · 2024Review
- Memory ability and retention performance relate differentially to sleep depth and spindle type.iScience · 2023Article
- Dynamic networks of cortico-muscular interactions in sleep and neurodegenerative disorders.Frontiers in network physiology · 2023Article
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
Sleep slow oscillations (SOs, 0.5-1.5 Hz) are thought to organize activity across cortical and subcortical structures, leading to selective synaptic changes that mediate consolidation of recent memories. Currently, the specific mechanism that allows for this selectively coherent activation across brain regions is not understood. Our previous research has shown that SOs can be classified on the scalp as Global, Local or Frontal, where Global SOs are found in most electrodes within a short time delay and gate long-range information flow during NREM sleep. The functional significance of space-time profiles of SOs hinges on testing if these differential SOs scalp profiles are mirrored by differential depth structure of SOs in the brain. In this study, we built an analytical framework to allow for the characterization of SO depth profiles in space-time across cortical and sub-cortical regions. To test if the two SO types could be differentiated in their cortical-subcortical activity, we trained 30 machine learning classification algorithms to distinguish Global and non-Global SOs within each individual, and repeated this analysis for light (Stage 2, S2) and deep (slow wave sleep, SWS) NREM stages separately. Multiple algorithms reached high performance across all participants, in particular algorithms based on k-nearest neighbors classification principles. Univariate feature ranking and selection showed that the most differentiating features for Global vs. non-Global SOs appeared around the trough of the SO, and in regions including cortex, thalamus, caudate nucleus, and brainstem. Results also indicated that differentiation during S2 required an extended network of current from cortical-subcortical regions, including all regions found in SWS and other basal ganglia regions, and amygdala and hippocampus, suggesting a potential functional differentiation in the role of Global SOs in S2 vs. SWS. We interpret our results as supporting the potential functional difference of Global and non-Global SOs in sleep dynamics.
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