Evidence map›Paper›PMID 36926093›Full record

ArticleFrontiers in network physiology2022

A Peri-Ictal EEG-Based Biomarker for Sudden Unexpected Death in Epilepsy (SUDEP) Derived From Brain Network Analysis.

Uilki Tufa, Adam Gravitis, Katherine Zukotynski, Yotin Chinvarun, Orrin Devinsky, Richard Wennberg, Peter L Carlen, Berj L Bardakjian

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Article in Frontiers in network physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Uilki TufaInstitute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
Adam GravitisInstitute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
Katherine ZukotynskiEdward S. Rogers Sr. Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON, Canada.
Yotin ChinvarunComprehensive Epilepsy Program and Neurology Unit, Phramongkutklao Hospital, Bangkok, Thailand.
Orrin DevinskyDepartment of Neurology, New York University School of Medicine, New York, NY, United States.
Richard WennbergDivision of Neurology, Toronto Western Hospital, Toronto, ON, Canada.
Peter L CarlenInstitute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
Berj L BardakjianInstitute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sudden unexpected death in epilepsy (SUDEP) is the leading seizure-related cause of death in epilepsy patients. There are no validated biomarkers of SUDEP risk. Here, we explored peri-ictal differences in topological brain network properties from scalp EEG recordings of SUDEP victims. Functional connectivity networks were constructed and examined as directed graphs derived from undirected delta and high frequency oscillation (HFO) EEG coherence networks in eight SUDEP and 14 non-SUDEP epileptic patients. These networks were proxies for information flow at different spatiotemporal scales, where low frequency oscillations coordinate large-scale activity driving local HFOs. The clustering coefficient and global efficiency of the network were higher in the SUDEP group pre-ictally, ictally and post-ictally (

Indexed as

brain dynamicsbrain networkselectroencephalographyepilepsyfunctional brain connectivityseizuresSUDEP (sudden unexpected death in epilepsy)

Identifiers

PMID36926093
PMCPMC10013055

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.