ArticleFrontiers in network physiology2022
Perspectives on Understanding Aberrant Brain Networks in Epilepsy.
Article in Frontiers in network physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Editorial: The network theory of epilepsy at twenty.Frontiers in network physiology · 2026Article
- Power-to-power cross-frequency coupling as a novel approach for temporal lobe seizure detection and analysis.Neuroscience informatics · 2025Article
- Massive Activation of GABABiomolecules · 2025Review
- Longitudinal alterations in brain networks and thalamocortical connectivity in paediatric focal epilepsy: a structural connectomics pilot study.Brain communications · 2025Article
- Spatial and spectral structure of local functional connectivity of the background intracranial EEG in patients with focal epilepsy.Frontiers in network physiology · 2025Article
- Memory Decline and Aberration of Synaptic Proteins in X-Linked Moesin Knockout Male Mice.Psychiatry investigation · 2025Article
- Preictal connectivity dynamics: Exploring inflow and outflow in iEEG networks.Frontiers in network physiology · 2025Article
- A statistical analysis method for probability distributions in Erdös-Rényi random networks with preferential cutting-rewiring operation.Frontiers in network physiology · 2024Article
- Electroencephalography derived connectivity informing epilepsy surgical planning: Towards clinical applications and future perspectives.NeuroImage. Clinical · 2024Review
- Seizure forecasting: Where do we stand?Epilepsia · 2023Article
- Resting state functional connectivity demonstrates increased segregation in bilateral temporal lobe epilepsy.Epilepsia · 2023Article
- The time-evolving epileptic brain network: concepts, definitions, accomplishments, perspectives.Frontiers in network physiology · 2023Review
- Dynamic networks of cortico-muscular interactions in sleep and neurodegenerative disorders.Frontiers in network physiology · 2023Article
- Modifying functional brain networks in focal epilepsy by manual visceral-osteopathic stimulation of the vagus nerve at the abdomen.Frontiers in network physiology · 2023Article
- Chronicles of Change: The Shrinking Brain in Epilepsy.Epilepsy currentsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
Epilepsy is a neurological disorder affecting approximately 70 million people worldwide. It is characterized by seizures that are complex aberrant dynamical events typically treated with drugs and surgery. Unfortunately, not all patients become seizure-free, and there is an opportunity for novel approaches to treat epilepsy using a network view of the brain. The traditional seizure focus theory presumed that seizures originated within a discrete cortical area with subsequent recruitment of adjacent cortices with seizure progression. However, a more recent view challenges this concept, suggesting that epilepsy is a network disease, and both focal and generalized seizures arise from aberrant activity in a distributed network. Changes in the anatomical configuration or widespread neural activities spanning lobes and hemispheres could make the brain more susceptible to seizures. In this perspective paper, we summarize the current state of knowledge, address several important challenges that could further improve our understanding of the human brain in epilepsy, and invite novel studies addressing these challenges.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.