ArticleFrontiers in neuroscience2023
Assessment of normal myelination in infants and young children using the T1w/T2w mapping technique.
Article in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Infant Brain Age Estimation With T1w/T2w Ratio MRI: A Myelination-Aware Deep Learning Approach.Journal of magnetic resonance imaging : JMRI · 2026Article
- Cortical and white matter myelination proceed in concert during early infancy.Nature communications · 2026Article
- T1-weighted/T2-weighted ratio reflects microstructural changes in Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- Dynamics of infant white matter maturation from birth to 6 months.Communications biology · 2026Article
- Exploratory analysis of high-altitude effects on brain morphology and myelination in native Tibetan infants.Translational pediatrics · 2026Article
- Extending the Branches of Neonatal Neurocritical Care.Seminars in perinatology · 2025Review
- Cortical and white matter T1w/T2w development proceed in concert during early infancy.bioRxiv : the preprint server for biology · 2025Article
- The Role of Proton Magnetic Resonance Spectroscopy in Neonatal and Fetal Brain Research.Journal of magnetic resonance imaging : JMRI · 2025Review
- Article
- Development of Myelin Growth Charts of the White Matter Using T1 Relaxometry.AJNR. American journal of neuroradiology · 2024Article
- Characterisation of the neonatal brain using myelin-sensitive magnetisation transfer imaging.Imaging neuroscience (Cambridge, Mass.) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: White matter myelination is a crucial process of CNS maturation. The purpose of this study was to validate the T1w/T2w mapping technique for brain myelination assessment in infants and young children. Methods: Ninety-four patients (0-23 months of age) without structural abnormalities on brain MRI were evaluated by using the T1w/T2w mapping method. The T1w/T2w signal intensity ratio, which reflects white matter integrity and the degree of myelination, was calculated in various brain regions. We performed a Pearson correlation analysis, a LOESS regression analysis, and a 2 Results: T1w/T2w ratio values rapidly increased in the first 6-9 months of life and then slowed thereafter. The T1w/T2w mapping technique emphasized the contrast between myelinated and less myelinated structures in all age groups, which resulted in better visualization. There were strong positive correlations between the T1w/T2w ratio values from the majority of white matter ROIs and the subjects' age ( Conclusion: The T1w/T2w mapping technique may enhance our diagnostic ability to assess myelination patterns in the brains of infants and young children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.