ArticleBioengineering & translational medicine2023
Peptide-functionalized double network hydrogel with compressible shape memory effect for intervertebral disc regeneration.
Article in Bioengineering & translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Biomaterials for intervertebral disc regeneration: Niche reprogramming, precision therapeutics, and structural reconstruction.Bioactive materials · 2027Review
- Application of hydrogel technologies in the treatment of musculoskeletal disorders.Chinese medical journal · 2026Review
- Stem Cells and their Key Derivatives in Degenerative Musculoskeletal Diseases.Stem cell reviews and reports · 2026Review
- Harnessing biopolymeric double network hydrogels for cartilage repair: a review of current strategies.Journal of materials science. Materials in medicine · 2026Review
- Advanced Design Concepts for Shape-Memory Polymers in Biomedical Applications and Soft Robotics.Polymers · 2026Review
- Mesenchymal stem cell and exosome-based therapies for degenerative disc disease: from mechanisms to clinical translation.Frontiers in cell and developmental biology · 2026Review
- Integrating cells, scaffolds, and molecular regulation: a mechanobiological and translational review of bioengineering therapies for intervertebral disc degeneration.Frontiers in bioengineering and biotechnology · 2026Review
- Self-assembled hybrid hydrogel microspheres create a bone marrow-mimicking niche for bone regeneration.Bioactive materials · 2025Article
- Shape memory hydrogels in tissue engineering: Recent advances and challenges.Bioactive materials · 2025Review
- Engineering Intervertebral Disc Regeneration: Biomaterials, Cell Sources and Animal Models.Cell proliferation · 2025Review
- Polysaccharide-based biomaterials for regenerative therapy in intervertebral disc degeneration.Materials today. Bio · 2025Review
- Cell-recruited microspheres for OA treatment by dual-modulating inflammatory and chondrocyte metabolism.Materials today. Bio · 2024Article
- Immune-defensive microspheres promote regeneration of the nucleus pulposus by targeted entrapment of the inflammatory cascade during intervertebral disc degeneration.Bioactive materials · 2024Article
- Shape Memory Hydrogels for Biomedical Applications.Gels (Basel, Switzerland) · 2024Review
- Single-Cell Microgel Encapsulation Improves the Therapeutic Efficacy of Mesenchymal Stem Cells in Treating Intervertebral Disc Degeneration via Inhibiting Pyroptosis.Research (Washington, D.C.) · 2024Article
- Shape-memory collagen scaffold combined with hyaluronic acid for repairing intervertebral disc.Biomaterials research · 2023Article
- Peptide-functionalized double network hydrogel with compressible shape memory effect for intervertebral disc regeneration.Bioengineering & translational medicine · 2023Article
- Application and development of hydrogel biomaterials for the treatment of intervertebral disc degeneration: a literature review.Frontiers in cell and developmental biology · 2023Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a prominent approach to treat intervertebral disc (IVD) degeneration, disc transplantation still falls short to fully reconstruct and restore the function of native IVD. Here, we introduce an IVD scaffold consists of a cellulose-alginate double network hydrogel-based annulus fibrosus (AF) and a cellulose hydrogel-based nucleus pulposus (NP). This scaffold mimics native IVD structure and controls the delivery of Growth Differentiation Factor-5 (GDF-5), which induces differentiation of endogenous mesenchymal stem cells (MSCs). In addition, this IVD scaffold has modifications on MSC homing peptide and RGD peptide which facilitate the recruitment of MSCs to injured area and enhances their cell adhesion property. The benefits of this double network hydrogel are high compressibility, shape memory effect, and mechanical strength comparable to native IVD. In vivo animal study demonstrates successful reconstruction of injured IVD including both AF and NP. These findings suggest that this double network hydrogel can serve as a promising approach to IVD regeneration with other potential biomedical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.