Evidence map›Paper›PMID 36925714›Full record

ReviewBioengineering & translational medicine2023

Micro and nanotechnologies: The little formulations that could.

Rebeca T Stiepel, Eliza Duggan, Cole J Batty, Kristy M Ainslie

Open access · goldFull text readReview
In one paragraph

Review in Bioengineering & translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
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  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Nano-Drug Delivery Systems Based on Natural Products.International journal of nanomedicine · 2024
    Review
  9. Review
  10. Article
  11. Micro and nanotechnologies: The little formulations that could.Bioengineering & translational medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Rebeca T StiepelDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy University of North Carolina Chapel Hill North Carolina USA.ORCID https://orcid.org/0000-0001-6943-8818
Eliza DugganNorth Carolina School of Science and Mathematics Durham North Carolina USA.ORCID https://orcid.org/0000-0003-2026-230X
Cole J BattyDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy University of North Carolina Chapel Hill North Carolina USA.ORCID https://orcid.org/0000-0001-6529-5004
Kristy M AinslieDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy University of North Carolina Chapel Hill North Carolina USA.ORCID https://orcid.org/0000-0002-1820-8382
University of North Carolina at Chapel Hill · USNorth Carolina School of Science and Mathematics · US

Funding

Optimizing a Universal Influenza Subunit Nano/Microparticulate VaccineR01AI147497 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AINSLIE, KRISTY M · 2020 to 2024
$2.9M
NIAID NIH HHS R01 AI147497
6 · The paper itself

Abstract

The first publication of micro- and nanotechnology in medicine was in 1798 with the use of the Cowpox virus by Edward Jenner as an attenuated vaccine against Smallpox. Since then, there has been an explosion of micro- and nanotechnologies for medical applications. The breadth of these micro- and nanotechnologies is discussed in this piece, presenting the date of their first report and their latest progression (e.g., clinical trials, FDA approval). This includes successes such as the recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines from Pfizer, Moderna, and Janssen (Johnson & Johnson) as well as the most popular nanoparticle therapy, liposomal Doxil. However, the enormity of the success of these platforms has not been without challenges. For example, we discuss why the production of Doxil was halted for several years, and the bankruptcy of BIND therapeutics, which relied on a nanoparticle drug carrier. Overall, the field of micro- and nanotechnology has advanced beyond these challenges and continues advancing new and novel platforms that have transformed therapies, vaccines, and imaging. In this review, a wide range of biomedical micro- and nanotechnology is discussed to serve as a primer to the field and provide an accessible summary of clinically relevant micro- and nanotechnology platforms.

Indexed as

imaging agentsinorganiclipid nanoparticlesnanoparticlesPEGvaccines

Identifiers

PMID36925714
PMCPMC10013823
OpenAlexW4306691518

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read25
identifiers read18
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.