Evidence map›Paper›PMID 36925701›Full record

ArticleBioengineering & translational medicine2023

Synergy of antioxidant and M2 polarization in polyphenol-modified konjac glucomannan dressing for remodeling wound healing microenvironment.

Huiyang Li, Xiaoyu Liang, Youlu Chen, Kaijing Liu, Xue Fu, Chuangnian Zhang, Xiaoli Wang, Jing Yang

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering & translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Huiyang LiTianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College Tianjin China.
Xiaoyu LiangTianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College Tianjin China.
Youlu ChenTianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College Tianjin China.
Kaijing LiuTianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College Tianjin China.
Xue FuTianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College Tianjin China.
Chuangnian ZhangTianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College Tianjin China.
Xiaoli WangTianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College Tianjin China.
Jing YangTianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College Tianjin China.ORCID https://orcid.org/0000-0003-3848-5958
Chinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Effective skin wound healing and tissue regeneration remain a challenge. Excessive/chronic inflammation inhibits wound healing, leading to scar formation. Herein, we report a wound dressing composed of KGM-GA based on the natural substances konjac glucomannan (KGM) and gallic acid (GA) that accelerates wound healing without any additional drugs. An in vitro study showed that KGM-GA could not only stimulate macrophage polarization to the anti-inflammatory M2 phenotype but also decrease reactive oxygen species (ROS) levels, indicating excellent anti-inflammatory properties. Moreover, in vivo studies of skin wounds demonstrated that the KGM-GA dressing significantly improved wound healing by accelerating wound closure, collagen deposition, and angiogenesis. In addition, it was observed that KGM-GA regulated M2 polarization, reducing the production of intracellular ROS in the wound microenvironment, which was consistent with the in vitro experiments. Therefore, this study designed a multifunctional biomaterial with biological activity, providing a novel dressing for wound healing.

Indexed as

bioactive dressingM2 macrophageROS scavengingwound healing

Identifiers

PMID36925701
PMCPMC10013815
OpenAlexW4293740176

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read82
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.