Trial reportThe Journal of nutrition2023
Long-Term Association Between Maternal Preconception Hemoglobin Concentration, Anemia, and Child Health and Development in Vietnam.
Trial report in The Journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between maternal anemia and neonatal anemia: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- Trial
- Child Hemoglobin Trajectories across the First 10 Years of Life and Association with Child Cognition and Academic Achievement at 10-11 Years.The Journal of nutrition · 2026Article
- Maternal nutrition practices and its implications for child growth and development in Jimma Town a community based cross sectional study.Scientific reports · 2026Article
- Factors Associated with Utilization of Preconception Care Among Pregnant Women Attending Antenatal Care at a Tertiary Hospital, Northern Uganda.International journal of women's health · 2026Article
- Getting back on track to meet global anaemia reduction targets: a Lancet Haematology Commission.The Lancet. Haematology · 2025Review
- Effects of preconception nutrition interventions on pregnancy and birth outcomes in South Asia: a systematic review.The Lancet regional health. Southeast Asia · 2025Review
- Preconception malnutrition among women and girls in south Asia: prevalence, determinants, and association with pregnancy and birth outcomes.The Lancet regional health. Southeast Asia · 2025Review
- The influence of nutritional status, the home environment, and schooling on behavioral outcomes of hyperactivity and inattention among grade-school children in rural Nepal.PLOS global public health · 2025Article
- The Association of Infant Birth Sizes and Anemia under Five Years Old: A Population-Based Prospective Cohort Study in China.Nutrients · 2024Article
- Prevalence and risk factors of anemia in the mother-child population from a region of the Colombian Caribbean.BMC public health · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe long-term association between preconception maternal hemoglobin (Hb) concentrations and child health and development is unclear.
objectivesWe examined associations between maternal preconception Hb concentrations and anemia with 1) birth outcomes (weight, length, preterm, gestational age, small for gestational age); 2) child Hb at 3 mo, 6 mo, 12 mo, and 24 mo; and 3) motor and mental development at 12 mo and 24 mo (Bayley scales for infant development) and cognitive functioning at 6-7 y (Wechsler Intelligence Scale for Children).
methodsWe used data from a randomized controlled trial (PRECONCEPT) conducted in Vietnam. Over 5000 women who were intending to conceive were recruited, and offspring were prospectively followed from birth (n = 1599) through 6-7 y (n = 1318). Multivariable linear and logistic regressions were used to assess the association between preconception Hb or anemia (Hb < 12g/dL) on child health and development outcomes, adjusted by supplementation group (tested for interactions) and confounding at maternal, child, and household levels.
resultsAt preconception enrollment, 20% of the women were anemic. Maternal preconception Hb was positively associated with child Hb at 3 mo (0.06; 95% CI: 0.01, 0.12), 6 mo (0.08; 95% CI: 0.03, 0.13), 12 mo (0.10; 95% CI: 0.04, 0.15), and 24 mo (0.07; 95% CI: 0.02, 0.12). Likewise, maternal preconception Hb was associated with reduced risk of child anemia at 6 mo (0.89; 95% CI: 0.81, 0.98), 12 mo (0.81; 95% CI: 0.74, 0.89), and 24 mo (0.87; 95% CI: 0.79, 0.95). Maternal preconception anemia was negatively associated with cognition (-1.64; 95% CI: -3.09, -0.19) and language development (-1.61; 95% CI: -3.20, -0.03) at 24 mo. Preconception Hb was not associated with birth outcomes or cognitive outcomes at 6-7 y.
conclusionsMaternal preconception Hb was associated with child Hb across the first 1000 d of life. However, preconception Hb was not a significant predictor of birth outcomes or cognitive outcomes at 6-7 y in this cohort from Vietnam. CLINICAL
trial registrationPRECONCEPT study (NCT: 01665378).
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