ArticleCurrent biology : CB2023
Neuronal birthdate reveals topography in a vestibular brainstem circuit for gaze stabilization.
Article in Current biology : CB, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- CLOK: a chemigenetic multicolor labeling system to visualize neuronal birthdate and circuit integration.Nature neuroscience · 2026Article
- Directionally biased neuronal responses to pitch-axis vestibular stimulation in larval zebrafish compared to roll-axis responses.Communications biology · 2026Article
- Transcriptional profiling of extraocular motor neurons revealsbioRxiv : the preprint server for biology · 2026Article
- Head stabilization behavior and underlying circuit mechanisms in larval zebrafish.Communications biology · 2026Article
- Birthdate aligns vestibular sensory neurons with central and motor partners across a sensorimotor reflex circuit for gaze stabilization.Development (Cambridge, England) · 2026Article
- Mechanistic research on the vestibular-hippocampal pathway in neurodegenerative diseases: an integrative perspective from molecular to behavioral levels.Frontiers in neuroscience · 2026Review
- Oligodendrocytes support functional development of subcortical premotor neurons and navigation.bioRxiv : the preprint server for biology · 2025Article
- Concurrent temporal patterning of neural stem cells in the fly visual system.Nature communications · 2025Article
- Influence of semicircular canal morphology on the VOR and swimming activity in larval amphibians: a comparative study inFrontiers in neurology · 2025Article
- Development of the semicircular canals and otolithic organs of the vertebrate inner ear.Current topics in developmental biology · 2025Review
- Motor neurons are dispensable for the assembly of a sensorimotor circuit for gaze stabilization.eLife · 2024Article
- Evolutionarily conserved brainstem architecture enables gravity-guided vertical navigation.PLoS biology · 2024Article
- Evolution and development of extraocular motor neurons, nerves and muscles in vertebrates.Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft · 2024Review
- A brainstem circuit for gravity-guided vertical navigation.bioRxiv : the preprint server for biology · 2024Article
- The conserved RNA-binding protein Imp is required for the specification and function of olfactory navigation circuitry in Drosophila.Current biology : CB · 2024Article
- Motor neurons are dispensable for the assembly of a sensorimotor circuit for gaze stabilization.bioRxiv : the preprint server for biology · 2024Article
- Article
- The Nature and Origin of Synaptic Inputs to Vestibulospinal Neurons in the Larval Zebrafish.eNeuro · 2023Article
- The RNA-binding protein, Imp specifies olfactory navigation circuitry and behavior inbioRxiv : the preprint server for biology · 2023Article
- The nature and origin of synaptic inputs to vestibulospinal neurons in the larval zebrafish.bioRxiv : the preprint server for biology · 2023Article
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Authors and funding
11 authors.
Funding
Abstract
Across the nervous system, neurons with similar attributes are topographically organized. This topography reflects developmental pressures. Oddly, vestibular (balance) nuclei are thought to be disorganized. By measuring activity in birthdated neurons, we revealed a functional map within the central vestibular projection nucleus that stabilizes gaze in the larval zebrafish. We first discovered that both somatic position and stimulus selectivity follow projection neuron birthdate. Next, with electron microscopy and loss-of-function assays, we found that patterns of peripheral innervation to projection neurons were similarly organized by birthdate. Finally, birthdate revealed spatial patterns of axonal arborization and synapse formation to projection neuron outputs. Collectively, we find that development reveals previously hidden organization to the input, processing, and output layers of a highly conserved vertebrate sensorimotor circuit. The spatial and temporal attributes we uncover constrain the developmental mechanisms that may specify the fate, function, and organization of vestibulo-ocular reflex neurons. More broadly, our data suggest that, like invertebrates, temporal mechanisms may assemble vertebrate sensorimotor architecture.
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