Evidence map›Paper›PMID 36924751›Full record

ReviewThe American journal of emergency medicine2023

Toxicities of herbal abortifacients.

Chris Feng, Kathryn E Fay, Michele M Burns

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The American journal of emergency medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Tetanus Infection Complicating an Unsafe Abortion with Resulting Maternal Mortality: A Case Report.Nigerian medical journal : journal of the Nigeria Medical Association
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Chris FengHarvard Medical Toxicology, Division of Emergency Medicine, Boston Children's Hospital, Boston, MA, USA. Electronic address: chris.feng@childrens.harvard.edu.
Kathryn E FayDepartment of Obstetrics, Gynecology and Reproductive Medicine, Harvard Medical School, Boston, MA, USA.
Michele M BurnsHarvard Medical Toxicology, Division of Emergency Medicine, Boston Children's Hospital, Boston, MA, USA.
Boston Children's Hospital · USHarvard University · US

Funding

Transdisciplinary Harvard WRHR Career Development for Gynecologists and ObstetriciansK12HD103096 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI NOUR, NAWAL M. · 2020 to 2024
$1.5M
NICHD NIH HHS K12 HD103096
6 · The paper itself

Abstract

backgroundIn the post-Roe era, barriers to facility-based abortions may lead to an increased incidence of self-managed abortions. While misoprostol-based medication abortions have significant literature supporting its safety profile, there is a knowledge deficit within the medical community regarding the toxicities of commonly used herbal abortifacients.

methodsThis is a narrative review, based on a MEDLINE and HOLLIS database search, of self-managed abortion methods with herbal abortifacients and their associated toxicities.

resultsCommon herbal abortifacients with significant morbidity and mortality implications include pennyroyal, blue cohosh, rue, and quinine. Other commonly reported abortifacients considered to be less toxic also are discussed in brief. Special considerations for hepatic, cardiac, renal, and hematologic toxicities are important in patients with significant exposures to these herbal substances.

conclusionThere is an anticipated increase in the utility of herbal xenobiotics for self-managed abortions with post-Roe restrictions to standard mifepristone-misoprostol protocols. Frontline providers should be aware of the associated toxicities and have special considerations when treating a poisoned patient in this population.

Indexed as

Abortifacient AgentsAbortion, InducedMisoprostolFemaleHumansMifepristonePregnancyAbortifacient AgentsMifepristoneMisoprostolAbortifacient toxicityEmergency careHerbal abortifacientSelf-managed abortion

Identifiers

PMID36924751
PMCPMC10192026
OpenAlexW4323351105

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.