Evidence map›Paper›PMID 36924550›Full record

ArticleSurgical oncology2023

The COVID - AGICT study: COVID-19 and advanced gastro-intestinal cancer surgical treatment. A multicentric Italian study on the SARS-CoV-2 pandemic impact on gastro-intestinal cancers surgical treatment during the 2020. Analysis of perioperative and short-term oncological outcomes.

Giuseppe Giuliani, Francesco Guerra, Simona Messinese, Francesco Santelli, Lucia Salvischiani, Sofia Esposito, Luca Ferraro, Alessandro Esposito, Matteo De Pastena, Daniela Rega and 60 more

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In one paragraph

Article in Surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

70 authors at 20 institutions in 1 country.

Giuseppe GiulianiDepartment of General and Emergency Surgery, Misericordia Hospital, Azienda Usl Toscana Sud Est. School of Robotic Surgery, Grosseto, Italy.
Francesco GuerraDepartment of General and Emergency Surgery, Misericordia Hospital, Azienda Usl Toscana Sud Est. School of Robotic Surgery, Grosseto, Italy.
Simona MessineseMedical Oncology Unit, Misericordia Hospital, Grosseto, Italy.
Francesco SantelliDepartment of Economics, Business, Mathematics and Statistics (DEAMS), University of Trieste, Trieste, Italy.
Lucia SalvischianiDepartment of General and Emergency Surgery, Misericordia Hospital, Azienda Usl Toscana Sud Est. School of Robotic Surgery, Grosseto, Italy.
Sofia EspositoDepartment of General, Emergency Surgery and New Technologies, Baggiovara General Hospital, AOU Modena, Italy.
Luca FerraroDivision of General and Robotic Surgery, Dipartimento di Scienze della Salute, Università di Milano, ASST Santi Paolo e Carlo, 20142 Milano, Italy.
Alessandro EspositoDepartment of General and Pancreatic Surgery, The Pancreas Institute, University of Verona Hospital Trust, Piazzale L.A. Scuro, 10, 37134, Verona, Italy.
Matteo De PastenaDepartment of General and Pancreatic Surgery, The Pancreas Institute, University of Verona Hospital Trust, Piazzale L.A. Scuro, 10, 37134, Verona, Italy.
Daniela RegaColorectal Surgical Oncology, Abdominal Oncology Department, Fondazione Giovanni Pascale IRCCS, Naples, Italy.
Paolo DelrioColorectal Surgical Oncology, Abdominal Oncology Department, Fondazione Giovanni Pascale IRCCS, Naples, Italy.
Carlotta La RajaDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072, Milan, Italy; IRCCS Humanitas Research Hospital, Division of Colon and Rectal Surgery, Via Manzoni 56, Rozzano, 20089, Milan, Italy.
Antonino SpinelliDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072, Milan, Italy; IRCCS Humanitas Research Hospital, Division of Colon and Rectal Surgery, Via Manzoni 56, Rozzano, 20089, Milan, Italy.
Simonetta MassaronDivision of Gastrointestinal Surgery, San Raffaele Hospital, Milan, Italy.
Paola De NardiDivision of Gastrointestinal Surgery, San Raffaele Hospital, Milan, Italy.
Emanuele Federico KauffmannDivision of General and Transplant Surgery, University of Pisa, Pisa, Italy.
Ugo BoggiDivision of General and Transplant Surgery, University of Pisa, Pisa, Italy.
Simona DeiddaDepartment of Surgery, Colorectal Surgery Center, University of Cagliari, Cagliari, Italy.
Angelo RestivoDepartment of Surgery, Colorectal Surgery Center, University of Cagliari, Cagliari, Italy.
Alessandra MaranoGeneral and Specialist Surgery Department, Emergency General Surgery Unit, A.O.U. Città della Salute e della Scienza di Torino, Turin, Italy.
Felice BorghiOncological Surgery, Candiolo Cancer Institute-FPO-IRCCS, Candiolo, 10060, Torino, Italy.
Micaela PiccoliDepartment of General, Emergency Surgery and New Technologies, Baggiovara General Hospital, AOU Modena, Italy.
Norma DepalmaDepartment of General Surgery, "Vito Fazzi" Hospital, Piazza Muratore, 1-73100, Lecce, Italy.
Stefano D'UgoDepartment of General Surgery, "Vito Fazzi" Hospital, Piazza Muratore, 1-73100, Lecce, Italy.
Marcello SpampinatoDepartment of General Surgery, "Vito Fazzi" Hospital, Piazza Muratore, 1-73100, Lecce, Italy.
Federico CozzaniGeneral Surgery Unit, Parma University Hospital, Parma, Italy.
Paolo Del RioGeneral Surgery Unit, Parma University Hospital, Parma, Italy.
Rosa MarcellinaroDepartment of General Surgery, S. Eugenio Hospital, Piazzale dell'Umanesimo, 10, 00144, Rome, Italy.
Massimo CarliniDepartment of General Surgery, S. Eugenio Hospital, Piazzale dell'Umanesimo, 10, 00144, Rome, Italy.
Raffaele De RosaSurgical Oncology Surgery, IRCCS Policlinico San Martino, Genoa, Italy.
Stefano ScabiniSurgical Oncology Surgery, IRCCS Policlinico San Martino, Genoa, Italy.
Fabio MaielloDepartment of Surgery - General Surgery Unit, Hospital of Biella, Biella, Italy.
Roberto PolastriDepartment of Surgery - General Surgery Unit, Hospital of Biella, Biella, Italy.
Giulia TurriDepartment of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Unit of General and Hepatobiliary Surgery, University and Hospital Trust of Verona, 37134, Verona, Italy.
Corrado PedrazzaniDepartment of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Unit of General and Hepatobiliary Surgery, University and Hospital Trust of Verona, 37134, Verona, Italy.
Monica ZeseDepartment of General and Urgent Surgery, Santa Maria della Misericordia Hospital, Rovigo, Italy.
Dario PariniDepartment of General and Urgent Surgery, Santa Maria della Misericordia Hospital, Rovigo, Italy.
Andrea CasarilDepartment of Surgery, "Pederzoli" Hospital, Peschiera del Garda, Verona, Italy.
Gianluigi MorettoDepartment of Surgery, "Pederzoli" Hospital, Peschiera del Garda, Verona, Italy.
Antonio De LeoGeneral Surgery Unit, Sandro Pertini Hospital, ASL Roma 2, Via dei Monti Tiburtini, 385, 00157, Rome, Italy.
Marco CatarciGeneral Surgery Unit, Sandro Pertini Hospital, ASL Roma 2, Via dei Monti Tiburtini, 385, 00157, Rome, Italy.
Renza TrapaniDepartment of General Surgery, Ospedale San Biagio, ASL VCO, Domodossola, Italy.
Sandro ZontaDepartment of General Surgery, Ospedale San Biagio, ASL VCO, Domodossola, Italy.
Patrizia MarsanicSurgical Department, E. Agnelli Hospital, 10064, Pinerolo, Italy.
Andrea MuratoreSurgical Department, E. Agnelli Hospital, 10064, Pinerolo, Italy.
Gregorio Di FrancoGeneral Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Paradisa 2, 56125, Pisa, Italy.
Luca MorelliGeneral Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Paradisa 2, 56125, Pisa, Italy.
Alessandro CoppolaDipartimento di chirurgia, Sapienza Università di Roma, Rome, Italy.
Damiano CaputoResearch Unit of Generale Surgery, Department of Medicine and Surgery, University Campus Bio-Medico di Roma, Via Alvaro del Portillo 200, 00128, Rome, Italy; Operative Research Unit of General Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200 - 00128, Roma, Italy.
Jacopo AndreuccettiSecond General Surgery, ASST Spedali Civili di Brescia, Brescia, Italy.
Giusto PignataSecond General Surgery, ASST Spedali Civili di Brescia, Brescia, Italy.
Laura MastrangeloDivision of General and Emergency Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Elio JovineDivision of General and Emergency Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Michele MazzolaDivision of Minimally-Invasive Surgical Oncology, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore, 3 20162, Milan, Italy.
Giovanni FerrariDivision of Minimally-Invasive Surgical Oncology, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore, 3 20162, Milan, Italy.
Lorenzo MarianiGeneral Surgery, San Giovanni Battista Hospital, USL Umbria 2, Foligno, Italy.
Graziano CeccarelliGeneral Surgery, San Giovanni Battista Hospital, USL Umbria 2, Foligno, Italy.
Rocco GiuseppeHepatobiliary, Pancreatic and General Surgery Unit, Department of Surgery, Azienda Unità Sanitaria Locale Area Vasta Romagna, Santa Maria delle Croci - Ravenna Hospital, Ravenna, Italy.
Stefano BolzonHepatobiliary, Pancreatic and General Surgery Unit, Department of Surgery, Azienda Unità Sanitaria Locale Area Vasta Romagna, Santa Maria delle Croci - Ravenna Hospital, Ravenna, Italy.
Mariateresa GrassoS.C. Chirurgia Generale, Ospedale S.Andrea, Vercelli, Italy.
Silvio TestaS.C. Chirurgia Generale, Ospedale S.Andrea, Vercelli, Italy.
Paola GermaniSurgical Clinic Unit, University Hospital of Trieste, Trieste, Italy.
Nicolò de ManziniSurgical Clinic Unit, University Hospital of Trieste, Trieste, Italy.
Serena LangellaDepartment of General and Oncological Surgery, Mauriziano Hospital, Largo Turati 62, 10128, Turin, Italy.
Alessandro FerreroDepartment of General and Oncological Surgery, Mauriziano Hospital, Largo Turati 62, 10128, Turin, Italy.
Diego ColettaDepartment of Surgical Sciences, Policlinico Umberto I University Hospital, Sapienza University of Rome, Rome, Italy.
Paolo Pietro BianchiDivision of General and Robotic Surgery, Dipartimento di Scienze della Salute, Università di Milano, ASST Santi Paolo e Carlo, 20142 Milano, Italy.
Carmelo BengalaMedical Oncology Unit, Misericordia Hospital, Grosseto, Italy.
Andrea CorattiDepartment of General and Emergency Surgery, Misericordia Hospital, Azienda Usl Toscana Sud Est. School of Robotic Surgery, Grosseto, Italy.
COVID-AGICT Collaborative group
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITOspedale San Paolo · ITOspedale Misericordia - Grosseto · ITUniversity of Trieste · ITUniversity of Verona · ITOspedale Maggiore · ITAzienda Unità Sanitaria Locale Della Romagna · ITCampus Bio Medico University Hospital · ITUniversity of Pisa · ITASL Roma · ITAzienda Ospedaliero Universitaria San Giovanni Battista · ITAzienda USL di Bologna · ITCasa di Cura Villa Garda · ITHumanitas University · ITIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITOspedale Civile Edoardo Agnelli · ITOspedale degli Infermi · ITOspedale Santa Maria della Misericordia di Rovigo · ITOspedale Vito Fazzi · ITUniversity of Cagliari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis Italian multicentric retrospective study aimed to investigate the possible changes in outcomes of patients undergoing surgery for gastrointestinal cancers during the COVID-19 pandemic.

methodOur primary endpoint was to determine whether the pandemic scenario increased the rate of patients with colorectal, gastroesophageal, and pancreatic cancers resected at an advanced stage in 2020 compared to 2019. Considering different cancer staging systems, we divided tumors into early stages and advanced stages, using pathological outcomes. Furthermore, to assess the impact of the COVID-19 pandemic on surgical outcomes, perioperative data of both 2020 and 2019 were also examined.

resultsOverall, a total of 8250 patients, 4370 (53%) and 3880 (47%) were surgically treated during 2019 and 2020 respectively, in 62 Italian surgical Units. In 2020, the rate of patients treated with an advanced pathological stage was not different compared to 2019 (P = 0.25). Nevertheless, the analysis of quarters revealed that in the second half of 2020 the rate of advanced cancer resected, tented to be higher compared with the same months of 2019 (P = 0.05). During the pandemic year 'Charlson Comorbidity Index score of cancer patients (5.38 ± 2.08 vs 5.28 ± 2.22, P = 0.036), neoadjuvant treatments (23.9% vs. 19.5%, P < 0.001), rate of urgent diagnosis (24.2% vs 20.3%, P < 0.001), colorectal cancer urgent resection (9.4% vs. 7.37, P < 0.001), and the rate of positive nodes on the total nodes resected per surgery increased significantly (7 vs 9% - 2.02 ± 4.21 vs 2.39 ± 5.23, P < 0.001).

conclusionsAlthough the SARS-CoV-2 pandemic did not influence the pathological stage of colorectal, gastroesophageal, and pancreatic cancers at the time of surgery, our study revealed that the pandemic scenario negatively impacted on several perioperative and post-operative outcomes.

Indexed as

Colorectal NeoplasmsCOVID-19Pancreatic NeoplasmsHumansPandemicsRetrospective StudiesSARS-CoV-2Advanced cancerColorectal cancerCOVID-19Gastroesophageal cancerGastrointestinal cancersPancreatic cancer

Identifiers

PMID36924550
PMCPMC9892255
OpenAlexW4319024660

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