ArticleCell reports2023
Geometric transformation of cognitive maps for generalization across hippocampal-prefrontal circuits.
Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- A novel rat spatial inference task reveals rapid deduction of transitive relationships using schemas and deliberation.Behavioral neuroscience · 2026Article
- Dysfunction of hippocampal cells and its role in cognitive impairment.Neural regeneration research · 2026Article
- An abstract relational map emerges in the human medial prefrontal cortex with consolidation.Current biology : CB · 2026Article
- A Novel Cooperative Behavior Assay in Rats Reveals Distinct Social Coordination Strategies of Increasing Complexity and Social Reciprocity Deficits in a Model of Fragile X Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Regional specialization in prefrontal cortex manifests in the reliability of task progression codes.Neuron · 2026Article
- Decodanda: a Python toolbox for best-practice decoding and geometric analysis of neural representations.bioRxiv : the preprint server for biology · 2026Article
- Article
- A mathematical theory for understanding when abstract representations emerge in neural networks.ArXiv · 2026Article
- Neural geometry in the human hippocampus enables generalization across spatial position and gaze.ArXiv · 2026Article
- Neural population geometry and optimal coding of tasks with shared latent structure.Nature neuroscience · 2026Article
- A Novel Rat Spatial Inference Task Reveals Rapid Deduction of Transitive Relationships Using Schemas and Deliberation.bioRxiv : the preprint server for biology · 2025Article
- Nonspecific ensemble reactivation in mouse dentate gyrus disrupts spatial working memory.iScience · 2025Article
- Hippocampal-cortical interactions in the consolidation of social memory.Nature communications · 2025Article
- Hippocampal-Prefrontal Communication Subspaces Align with Behavioral and Network Patterns in a Spatial Memory Task.eNeuro · 2025Article
- New information triggers prospective codes to adapt for flexible navigation.Nature communications · 2025Article
- Article
- Three systems of circuit formation: assembly, updating and tuning.Nature reviews. Neuroscience · 2025Review
- Exploring replay.Nature communications · 2025Article
- Prefrontal cortex synchronization with the hippocampus and parietal cortex is strategy-dependent during spatial learning.Communications biology · 2025Article
- Sleep microstructure organizes memory replay.Nature · 2025Article
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Authors and funding
3 authors.
Funding
Abstract
The ability to abstract information to guide decisions during navigation across changing environments is essential for adaptation and requires the integrity of the hippocampal-prefrontal circuitry. The hippocampus encodes navigational information in a cognitive map, but it remains unclear how cognitive maps are transformed across hippocampal-prefrontal circuits to support abstraction and generalization. Here, we simultaneously record hippocampal-prefrontal ensembles as rats generalize navigational rules across distinct environments. We find that, whereas hippocampal representational maps maintain specificity of separate environments, prefrontal maps generalize across environments. Furthermore, while both maps are structured within a neural manifold of population activity, they have distinct representational geometries. Prefrontal geometry enables abstraction of rule-informative variables, a representational format that generalizes to novel conditions of existing variable classes. Hippocampal geometry lacks such abstraction. Together, these findings elucidate how cognitive maps are structured into distinct geometric representations to support abstraction and generalization while maintaining memory specificity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.