ArticleAnnals of medicine2023
Diabetes type 2: relationships between lysosomal exocytosis of circulating normal-sized platelets and
Article in Annals of medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Diabetes Type 2: Circulating Phosphatidylserine-Expressing Platelets Regulate Whole Blood Agonist-Evoked Platelet Activity In Vitro.TH open : companion journal to thrombosis and haemostasis · 2026Article
- Coagulation Function and Type 2 Diabetic Kidney Disease: A Real-World Observational Study.Journal of diabetes research · 2023Observational
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectiveType 2 diabetes is a major risk factor for atherosclerotic disease. It is well agreed that the reactivity of diabetic platelets is increased but how platelet reactivity regulates is unknown. In our laboratory, density separated platelets have been investigated extensively and high- and low-density platelets circulate in an activated state. The density distribution of circulating platelets is altered in diabetes type 2 as well. We hypothesize that such platelets modify whole blood (WB) PATIENTS AND
methodsPatients with type 2 diabetes (
resultsWith some exceptions, the proportion of normal-sized circulating platelets showing spontaneous LAMP-1 was strongly associated with WB ɑ-thrombin-evoked (10 U/mL) surface LAMP-1 and α
conclusionsFrom the current descriptive work only involving type 2 diabetes, it is impossible to judge whether the findings are features of the disease or if they occur in healthy individuals as well. However, the study describes LAMP-1 expressing subpopulations of circulating normal-sized platelets that associate with WB α-thrombin (10 U/mL) responses
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Registered trials
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