Evidence map›Paper›PMID 36924351›Full record

ArticleAnatomical record (Hoboken, N.J. : 2007)2025

Dose-related cardiac outcomes in response to postnatal dexamethasone treatment in premature lambs.

Amanda Vrselja, Jennifer Jane Pillow, Jonathan G Bensley, Siavash Ahmadi-Noorbakhsh, Peter B Noble, Mary Jane Black

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anatomical record (Hoboken, N.J. : 2007), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Amanda VrseljaDepartment of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0001-7845-6372
Jennifer Jane PillowSchool of Human Sciences, University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0002-6500-0138
Jonathan G BensleyDepartment of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0003-2926-1856
Siavash Ahmadi-NoorbakhshSchool of Human Sciences, University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0001-6293-670X
Peter B NobleSchool of Human Sciences, University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0001-9028-7751
Mary Jane BlackDepartment of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-9253-3773
Discovery Institute · USThe University of Western Australia · AU

Funding

Chiesi Farmaceutici S.p.A.Fisher and Paykel HealthcareICU MedicalMBio Postgraduate Discovery ScholarshipNational Health and Medical Research Council GNT1057514National Health and Medical Research Council GNT1057759National Health and Medical Research Council RF1077691Telethon Perth Children's Hospital Research Fund
6 · The paper itself

Abstract

backgroundPostnatal corticosteroids are used in the critical care of preterm infants for the prevention and treatment of bronchopulmonary dysplasia. We aimed to investigate the effects of early postnatal dexamethasone therapy and dose on cardiac maturation and morphology in preterm lambs.

methodsLambs were delivered prematurely at ~128 days of gestational age and managed postnatally according to best clinical practice. Preterm lambs were administered dexamethasone daily at either a low-dose (n = 9) or a high-dose (n = 7), or were naïve to steroid treatment and administered saline (n = 9), over a 7-day time-course. Hearts were studied at postnatal Day 7 for gene expression and assessment of myocardial structure.

resultsHigh-dose dexamethasone treatment in the early postnatal period led to marked differences in cardiac gene expression, altered cardiomyocyte maturation and reduced cardiomyocyte endowment in the right ventricle, as well as increased inflammatory infiltrates into the left ventricle. Low-dose exposure had minimal effects on the preterm heart.

conclusionNeonatal dexamethasone treatment led to adverse effects in the preterm heart in a dose-dependent manner within the first week of life. The observed cardiac changes associated with high-dose postnatal dexamethasone treatment may influence postnatal growth and remodeling of the preterm heart and subsequent long-term cardiac function.

Indexed as

DexamethasoneGlucocorticoidsHeartMyocardiumMyocytes, CardiacAnimalsAnimals, NewbornDose-Response Relationship, DrugFemaleSheepDexamethasoneGlucocorticoidscardiac remodelingdevelopmental programminginfant, prematuremyocardiummyocyte, cardiacpostnatal corticosteroidspremature birth

Identifiers

PMID36924351
PMCPMC11889478
OpenAlexW4327596645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.