Evidence map›Paper›PMID 36924296›Full record

ArticleCNS neuroscience & therapeutics2023

Analysis of positron emission tomography hypometabolic patterns and neuropsychiatric symptoms in patients with dementia syndromes.

Jinghuan Gan, Zhihong Shi, Chuantao Zuo, Xiaobin Zhao, Shuai Liu, Yongjie Chen, Nan Zhang, Li Cai, Ruixue Cui, Lin Ai and 2 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jinghuan GanDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China.
Zhihong ShiDepartment of Neurology, Tianjin Dementia Institute, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China.
Chuantao ZuoPET Center, Huashan Hospital, Fudan University, Shanghai, China.
Xiaobin ZhaoDepartment of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Shuai LiuDepartment of Neurology, Tianjin Dementia Institute, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China.
Yongjie ChenDepartment of Epidemiology and Statistics, School of Public Health, Tianjin Medical University, Tianjin, China.
Nan ZhangDepartment of Neurology, General Hospital of Tianjin Medical University, Tianjin, China.ORCID 0000-0002-9675-5322
Li CaiDepartment of PET-CT Diagnostics, Tianjin Medical University General Hospital, Tianjin, China.
Ruixue CuiDepartment of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Lin AiDepartment of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yi-Hui GuanPET Center, Huashan Hospital, Fudan University, Shanghai, China.
Yong JiDepartment of Neurology, Tianjin Dementia Institute, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China.ORCID 0000-0003-0745-1528

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo estimate the proportions of specific hypometabolic patterns and their association with neuropsychiatric symptoms (NPS) in patients with cognitive impairment (CI).

methodsThis multicenter study with 1037 consecutive patients was conducted from December 2012 to December 2019.

resultsPatients with clinical Alzheimer's disease (AD, 81.6%, 605/741) and dementia with Lewy bodies (67.9%, 19/28) mostly had AD-pattern hypometabolism, and 76/137 (55.5%) of patients with frontotemporal lobar degeneration showed frontal and anterior temporal pattern (FT-P) hypometabolism. Besides corticobasal degeneration, patients with behavioral variant frontotemporal dementia (36/58), semantic dementia (7/10), progressive non-fluent aphasia (6/9), frontotemporal lobar degeneration and amyotrophic lateral sclerosis (3/5), and progressive supranuclear palsy (21/37) also mostly showed FT-P hypometabolism. The proportion of FT-P hypometabolism was associated with the presence of hallucinations (R = 0.171, p = 0.04), anxiety (R = 0.182, p = 0.03), and appetite and eating abnormalities (R = 0.200, p = 0.01) in AD.

conclusionSpecific hypometabolic patterns in FDG-PET are associated with NPS and beneficial for the early identification and management of NPS in patients with CI.

Indexed as

Alzheimer DiseaseFrontotemporal DementiaFrontotemporal Lobar DegenerationBrainFluorodeoxyglucose F18HumansPositron-Emission TomographySyndromeFluorodeoxyglucose F18cognitive impairmentfluorodeoxyglucose positron emission tomographyfrontotemporal lobar degenerationhypometabolismneuropsychiatric symptom

Identifiers

PMID36924296
PMCPMC10352896

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