Evidence map›Paper›PMID 36924191›Full record

ArticleEuropean heart journal2023

Cardiac sarcoidosis: phenotypes, diagnosis, treatment, and prognosis.

Jukka Lehtonen, Valtteri Uusitalo, Pauli Pöyhönen, Mikko I Mäyränpää, Markku Kupari

Open access · bronzeAbstract read
In one paragraph

Article in European heart journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed
29.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 166 citations in OpenAlex.

  1. Review
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  9. Acute and Chronic Myocarditis in Men and Women.Current heart failure reports · 2026
    Review
  10. Article
  11. Diagnostic and prognostic value of T2 mapping in cardiac sarcoidosis.International journal of cardiology. Heart & vasculature · 2026
    Article
  12. The inflammatory fingerprint reveals immune cell populations associated with disease activity in cardiac sarcoidosis.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  13. Article
  14. Article
  15. Redefining Cardiac Sarcoidosis with Advanced Imaging and Therapeutic Strategies.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2026
    Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jukka LehtonenHeart and Lung Center, Helsinki University Central Hospital and University of Helsinki, Haartmaninkatu 4, 00290 Helsinki, Finland.ORCID 0000-0001-7637-6061
Valtteri UusitaloClinical Physiology and Nuclear Medicine, Helsinki University Central Hospital and University of Helsinki, Haartmaninkatu 4, 00290 Helsinki, Finland.ORCID 0000-0001-7345-7122
Pauli PöyhönenHeart and Lung Center, Helsinki University Central Hospital and University of Helsinki, Haartmaninkatu 4, 00290 Helsinki, Finland.ORCID 0000-0002-3031-5391
Mikko I MäyränpääDepartment of Pathology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 3C, 00290 Helsinki, Finland.ORCID 0000-0002-0877-9640
Markku KupariHeart and Lung Center, Helsinki University Central Hospital and University of Helsinki, Haartmaninkatu 4, 00290 Helsinki, Finland.ORCID 0000-0002-5813-3477
University of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac sarcoidosis (CS) results from epithelioid cell granulomas infiltrating the myocardium and predisposing to conduction disturbances, ventricular tachyarrhythmias, and heart failure. Manifest CS, however, constitutes only the top of an iceberg as advanced imaging uncovers cardiac involvement 4 to 5 times more commonly than what is clinically detectable. Definite diagnosis of CS requires myocardial biopsy and histopathology, but a sufficient diagnostic likelihood can be achieved by combining extracardiac histology of sarcoidosis with clinical manifestations and findings on cardiac imaging. CS can appear as the first or only organ manifestation of sarcoidosis or on top of pre-existing extracardiac disease. Due to the lack of controlled trials, the care of CS is based on observational evidence of low quality. Currently, the treatment involves corticosteroid-based, tiered immunosuppression to control myocardial inflammation with medical and device-based therapy for symptomatic atrioventricular block, ventricular tachyarrhythmias, and heart failure. Recent outcome data indicate 90% to 96% 5-year survival in manifest CS with the 10-year figures ranging from 80% to 90%. Major progress in the care of CS awaits the key to its molecular-genetic pathogenesis and large-scale controlled clinical trials.

Indexed as

CardiomyopathiesHeart FailureMyocarditisSarcoidosisTachycardia, VentricularHumansPhenotypePrognosisCardiac sarcoidosisHeart failureImplantable cardioverter-defibrillatorInflammatory heart diseasePacemaker

Identifiers

PMID36924191
PMCPMC10149532
OpenAlexW4327588594

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.