ArticleThe clinical respiratory journal2023
Cytomegalovirus serology in young to mid-adult life and decline of lung function.
Article in The clinical respiratory journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Pulmonary Immunocompromise in Human Immunodeficiency Virus Disease.Clinics in chest medicine · 2025Review
- A model of dysregulated crosstalk between dendritic, natural killer, and regulatory T cells in chronic obstructive pulmonary disease.Trends in immunology · 2024Article
- HIV-associated lung disease.Nature reviews. Disease primers · 2023Review
- Cytomegalovirus serology in young to mid-adult life and decline of lung function.The clinical respiratory journal · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
introductionCytomegalovirus (CMV) seropositivity has been recently linked to severity and progression of asthma, cystic fibrosis, and chronic obstructive pulmonary disease (COPD). To date, no longitudinal study has addressed the relation of CMV serology to levels and decline of lung function in the general adult population.
methodsWe evaluated 403 participants from the Tucson Epidemiological Study of Airway Obstructive Disease (TESAOD) who at enrollment were aged 28-55 years and completed lung function tests. During follow-up, the 403 participants completed on average 7.2 lung function tests per subject for a total of 2908 observations over a mean period of 14.7 years. We tested CMV serology in serum samples from enrollment and categorized participants into low, medium, and high CMV serology based on tertiles. The relation of CMV serology at enrollment to lung function levels and decline during follow-up was tested in multivariate random coefficients models.
resultsAfter full adjustment, participants in the highest CMV serology tertile had faster declines of forced expiratory volume in 1 s (FEV
conclusionHigh CMV serology in young to mid-adult life may be linked to increased COPD risk through an accelerated decline of lung function.
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Registered trials
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