Evidence map›Paper›PMID 36923939›Full record

ArticleInternational journal of biological sciences2023

Single-cell resolution reveals RalA GTPase expanding hematopoietic stem cells and facilitating of BCR-ABL1-driven leukemogenesis in a CRISPR/Cas9 gene editing mouse model.

Zhao Yin, Rui Su, Lanlan Ge, Xiuyuan Wang, Juhua Yang, Guiping Huang, Chuting Li, Yanjun Liu, Keda Zhang, Lan Deng and 1 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Zhao YinDepartment of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou 510632, China.
Rui SuDepartment of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou 510632, China.
Lanlan GeCenter Lab of Longhua Branch and Department of Infectious Disease, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University), Shenzhen, Guangdong 518020, China.
Xiuyuan WangDepartment of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou 510632, China.
Juhua YangDepartment of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou 510632, China.
Guiping HuangDepartment of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou 510632, China.
Chuting LiDepartment of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou 510632, China.
Yanjun LiuDepartment of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou 510632, China.
Keda ZhangCollege of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China.
Lan DengDepartment of Hematology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Jia FeiDepartment of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou 510632, China.
GCI Science & Technology (China) · CNJinan University · CNGuangdong Provincial People's Hospital · CNShanghai Ninth People's Hospital · CNShenzhen Technology University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BCR-ABL oncogene-mediated Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) is suggested to originate from leukemic stem cells (LSCs); however, factors regulating self-renewal of LSC and normal hematopoietic stem cells (HSCs) are largely unclear. Here, we show that RalA, a small GTPase in the Ras downstream signaling pathway, has a critical effect on regulating the self-renewal of LSCs and HSCs. A RalA knock-in mouse model (RalA

Indexed as

CRISPR-Cas SystemsLeukemia, Myelogenous, Chronic, BCR-ABL PositiveAnimalsCarcinogenesisGene EditingGTP PhosphohydrolasesGuanosine MonophosphateHematopoietic Stem CellsHumansMiceNeoplastic Stem Cellsral GTP-Binding ProteinsThionucleotidesGTP Phosphohydrolasesguanosine 5'-monophosphorothioateGuanosine MonophosphateRALA protein, humanral GTP-Binding ProteinsThionucleotidesimatinib resistanceleukemia stem cellsmouse model with gene editingnormal hematopoietic stem cellsRalA/single-cell resolution

Identifiers

PMID36923939
PMCPMC10008703
OpenAlexW4324009494

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read48
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.