Evidence map›Paper›PMID 36923554›Full record

ArticleCancer research communications2022

Efficacy of Low-Dose Aspirin in Colorectal Cancer Risk Prevention is Dependent on

Kanae Mure, Hideki Ishikawa, Michihiro Mutoh, Mano Horinaka, Takahiro Otani, Sadao Suzuki, Keiji Wakabayashi, Toshiyuki Sakai, J-FAPP Study IV group

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In one paragraph

Article in Cancer research communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Kanae MureDepartment of Public Health, Wakayama Medical University School of Medicine, Wakayama, Japan.ORCID 0000-0002-1395-0983
Hideki IshikawaDepartment of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Michihiro MutohDepartment of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Mano HorinakaDepartment of Drug Discovery Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Takahiro OtaniDepartment of Public Health, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.
Sadao SuzukiDepartment of Public Health, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.ORCID 0000-0001-5988-4849
Keiji WakabayashiGraduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan.
Toshiyuki SakaiDepartment of Drug Discovery Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
J-FAPP Study IV group
Kyoto Prefectural University · JPNagoya City University · JPUniversity of Shizuoka · JPWakayama Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aspirin has gained great attention as a cancer preventive agent. Our previous study revealed that the low-dose aspirin prevents colorectal tumor recurrence in Japanese patients with colorectal adenomas and/or adenocarcinomas, whereas aspirin increases risks in smokers and has no effects on regular drinkers. Our recent study revealed that aspirin reduces polyp growth in Japanese patients with familial adenomatous polyposis (FAP). In this study, we have studied the association of genotypes of alcohol metabolizing enzymes (ADH1B and ALDH2) on aspirin's efficacy of suppressing polyp growth (≥5 mm) in a total of 81 Japanese patients with FAP. Our study revealed that aspirin showed significant preventive effects for patients with Significance: Aspirin is beneficial to patients with FAP with

Indexed as

Adenomatous Polyposis ColiAspirinAlcohol DehydrogenaseAldehyde Dehydrogenase, MitochondrialColorectal NeoplasmsEast Asian PeopleGenotypeHumansNeoplasm Recurrence, LocalPolymorphism, GeneticADH1B protein, humanAlcohol DehydrogenaseAldehyde Dehydrogenase, MitochondrialALDH2 protein, humanAspirin

Identifiers

PMID36923554
PMCPMC10010329
OpenAlexW4281678955

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read34
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.