Evidence map›Paper›PMID 36923537›Full record

ArticleTheranostics2023

GLSP and GLSP-derived triterpenes attenuate atherosclerosis and aortic calcification by stimulating ABCA1/G1-mediated macrophage cholesterol efflux and inactivating RUNX2-mediated VSMC osteogenesis.

Guobin Zheng, Yun Zhao, Zhenhao Li, Yunqing Hua, Jing Zhang, Yaodong Miao, Yang Guo, Lan Li, Jia Shi, Zhengwei Dong and 3 more

Open access · goldFull text read
In one paragraph

Article in Theranostics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  11. Rodent Models for Atherosclerosis.International journal of molecular sciences · 2025
    Review
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  19. Review
  20. Frontiers in immunology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Guobin ZhengNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300134, China.
Yun ZhaoFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Zhenhao LiZhejiang ShouXianGu Botanical Drug Institute, Zhejiang Hangzhou 321200 China.
Yunqing HuaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Jing ZhangFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Yaodong MiaoSecond Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China.
Yang GuoNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
Lan LiFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Jia ShiFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Zhengwei DongFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Shu YangDepartment of Geriatrics, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), Shenzhen, China.
Guanwei FanFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Chuanrui MaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine · CNJinan University · CNTianjin Medical University · CNTianjin University of Traditional Chinese Medicine · CNZheJiang Institute For Food and Drug Control · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AtherosclerosisPlaque, AtheroscleroticReishiTriterpenesVascular CalcificationAnimalsATP Binding Cassette Transporter 1CholesterolCore Binding Factor Alpha 1 SubunitMacrophagesMaleMiceMice, KnockoutMuscle, Smooth, VascularOsteogenesisPowdersAbca1 protein, mouseATP Binding Cassette Transporter 1CholesterolCore Binding Factor Alpha 1 Subunitganoderic acidPowdersRunx2 protein, mouseTriterpenesaortic calcificationatherosclerosischolesterol metabolismGLSPtriterpenes

Identifiers

PMID36923537
PMCPMC10008734
OpenAlexW4324009740

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read65
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.