Evidence map›Paper›PMID 36923442›Full record

ArticleToxicology reports2023

Bisphenols, but not phthalate esters, modulate gene expression in activated human MAIT cells

J L Krause, A Pierzchalski, H D Chang, A C Zenclussen, M Bauer, G Herberth

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

J L KrauseHelmholtz-Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany.
A PierzchalskiHelmholtz-Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany.
H D ChangInstitute for Biotechnology, Technische Universität Berlin, Germany.
A C ZenclussenHelmholtz-Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany.
M BauerHelmholtz-Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany.
G HerberthHelmholtz-Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany.
Helmholtz Centre for Environmental Research · DETechnische Universität Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One route of human exposure to environmental chemicals is oral uptake. This is primarily true for chemicals that may leach from food packaging materials, such as bisphenols and phthalate esters. Upon ingestion, these compounds are transported along the intestinal tract, from where they can be taken up into the blood stream or distributed to mucosal sites. At mucosal sites, mucosal immune cells and in the blood stream peripheral immune cells may be exposed to these chemicals potentially modulating immune cell functions. In the present study, we investigated the impact of three common bisphenols and two phthalate esters on mucosal-associated invariant T (MAIT) cells

Indexed as

BisphenolsBPA, bisphenol Abpc, bacteria per cellBPF, bisphenol FBPS, bisphenol Sbw, body weightCD, cluster of differentiationDEHP, di(2-ethylhexyl) phthalateDINP, diisononyl phthalateDMSO, dimethyl sulfoxideEFSA, European Food Safety AgencyEU, European UnionFCS, fetal calf serumIFNg, interferon gammaIMDM, Iscove Modified Dulbecco MediumImmunomodulationIn vitro modelMAIT cellsMAIT cells, mucosal-associated invariant T cellsMeOH, methanolNHANES, National Health and Nutrition Examination SurveyPBMC, peripheral blood mononuclear cellPE, phthalate esterPhthalate esterPlasticizersRT, room temperatureSVHC, substance of very high concernTDI, tolerable daily intakeTNF, tumor necrosis factor

Identifiers

PMID36923442
PMCPMC10008924
OpenAlexW4322723692

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.