Evidence map›Paper›PMID 36923262›Full record

ReviewRheumatology advances in practice2023

Management of systemic sclerosis: British Society for Rheumatology guideline scope.

Christopher P Denton, Enrico De Lorenzis, Elen Roblin, Nina Goldman, Begonya Alcacer-Pitarch, Emma Blamont, Maya Buch, Maresa Carulli, Caroline Cotton, Francesco Del Galdo and 20 more

Registry-linked trialFull text readReview
In one paragraph

Review in Rheumatology advances in practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06297096 (Multicentre Clinical Trial Evaluating the Safety and Efficacy of the Combination of Nintedanib+Tocilizumab Compared to Standard Treatment in Patients With Systemic Sclerosis and Interstitial Lung Disease. Analysis With Theranostic Approach), which is not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06297096 phase3recruitingnot on this mapstarted 2025, after this paper: background citation

Multicentre Clinical Trial Evaluating the Safety and Efficacy of the Combination of Nintedanib+Tocilizumab Compared to Standard Treatment in Patients With Systemic Sclerosis and Interstitial Lung Disease. Analysis With Theranostic Approach

TypeinterventionalSponsorNational Institute of Geriatrics, Rheumatology and Rehabilitation, PolandRan2025 to 2028Enrolled86ConditionsSystemic Sclerosis, Interstitial Lung DiseaseArmsTocilizumab, Nintedanib, Standard therapy
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Guideline
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Christopher P DentonCentre for Rheumatology, Division of Medicine, University College London, London, UK.ORCID https://orcid.org/0000-0003-3975-8938
Enrico De LorenzisDepartment of Rheumatology, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
Elen RoblinCentre for Rheumatology, Royal Free London NHS Foundation Trust, London, UK.
Nina GoldmanCentre for Rheumatology, Division of Medicine, University College London, London, UK.
Begonya Alcacer-PitarchDepartment of Rheumatology, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
Emma BlamontScleroderma and Raynaud's UK, London, UK.
Maya BuchDepartment of Rheumatology, University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0002-8962-5642
Maresa CarulliDepartment of Rheumatology, Hammersmith Hospitals NHS Foundation Trust, London, UK.
Caroline CottonDepartment of Rheumatology, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
Francesco Del GaldoDepartment of Rheumatology, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.ORCID https://orcid.org/0000-0002-8528-2283
Emma Derrett-SmithDepartment of Rheumatology, University of Birmingham, Birmingham, UK.
Karen DouglasDepartment of Rheumatology, Dudley Group NHS Foundation Trust, Birmingham, UK.
Sue FarringtonDepartment of Rheumatology, University of Manchester, Manchester, UK.
Kim FligelstoneCentre for Rheumatology, Royal Free London NHS Foundation Trust, London, UK.
Luke GompelsDepartment of Rheumatology, Somerset NHS Foundation Trust, Taunton, UK.
Bridget GriffithsDepartment of Rheumatology, Freeman Hospital, Newcastle, UK.
Ariane HerrickDepartment of Rheumatology, Hammersmith Hospitals NHS Foundation Trust, London, UK.ORCID https://orcid.org/0000-0003-4941-7926
Michael HughesDepartment of Rheumatology, Hammersmith Hospitals NHS Foundation Trust, London, UK.
Clare PainDepartment of Rheumatology, Alder Hey Children's Hospital, Liverpool, UK.ORCID https://orcid.org/0000-0003-4965-3259
Georgina PantanoPatient representative, London, UK.
John PaulingDepartment of Rheumatology, North Bristol NHS Foundation Trust, Bristol, UK.ORCID https://orcid.org/0000-0002-2793-2364
Athiveeraramapandian PrabuDepartment of Rheumatology, University of Birmingham, Birmingham, UK.
Nuala O'DonoghueDepartment of Rheumatology, Salford Royal NHS Foundation Trust, Salford, UK.
Elisabetta RenzoniInterstitial Lung Disease Unit, Royal Brompton NHS Foundation Trust, London, UK.
Jeremy RoyleDepartment of Rheumatology, University Hospitals NHS Foundation Trust, Leicester, UK.
Muditha SamaranayakaDepartment of Rheumatology, Salford Royal NHS Foundation Trust, Salford, UK.
Julia SpieringsDepartment of Rheumatology, University of Utrecht, Utrecht, The Netherlands.
Aoife TynanCentre for Rheumatology, Royal Free London NHS Foundation Trust, London, UK.
Louise WarburtonPrimary Care Sciences, Keele University, Keele, UK.
Voon OngCentre for Rheumatology, Division of Medicine, University College London, London, UK.ORCID https://orcid.org/0000-0001-5474-0053

Funding

Versus Arthritis 20719Versus Arthritis 22398
6 · The paper itself

Abstract

This guideline will provide a practical roadmap for management of SSc that builds upon the previous treatment guideline to incorporate advances in evidence-based treatment and increased knowledge about assessment, classification and management. General approaches to management as well as treatment of specific complications will be covered, including lung, cardiac, renal and gastrointestinal tract disease, as well as RP, digital vasculopathy, skin manifestations, calcinosis and impact on quality of life. It will include guidance related to emerging approved therapies for interstitial lung disease and account for National Health Service England prescribing policies and national guidance relevant to SSc. The guideline will be developed using the methods and processes outlined in Creating Clinical Guidelines: Our Protocol. This development process to produce guidance, advice and recommendations for practice has National Institute for Health and Care Excellence accreditation.

Indexed as

guidelinemanagementpulmonary fibrosissclerodermaSSc

Identifiers

PMID36923262
PMCPMC10010890

What OpenQuestion holds

Textfull text, public
LicenceCC BY
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.