Evidence map›Paper›PMID 36923255›Full record

ReviewFrontiers in cell and developmental biology2023

Bioengineered MSC-derived exosomes in skin wound repair and regeneration.

Hanxing Zhao, Zhengyong Li, Yixi Wang, Kai Zhou, Hairui Li, Siwei Bi, Yudong Wang, Wenqing Wu, Yeqian Huang, Bo Peng and 5 more

Open access · goldFull text readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 2 pooled it
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.

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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Hanxing ZhaoDepartment of Plastic and Burn Surgery, West China Hospital, Sichuan University, Chengdu, China.
Zhengyong LiDepartment of Plastic and Burn Surgery, West China Hospital, Sichuan University, Chengdu, China.
Yixi WangDepartment of Plastic and Burn Surgery, West China Hospital, Sichuan University, Chengdu, China.
Kai ZhouDepartment of Plastic Reconstructive and Aesthetic Surgery, West China Tianfu Hospital, Sichuan University, Chengdu, China.
Hairui LiDepartment of Plastic Reconstructive and Aesthetic Surgery, West China Tianfu Hospital, Sichuan University, Chengdu, China.
Siwei BiDepartment of Plastic and Burn Surgery, West China Hospital, Sichuan University, Chengdu, China.
Yudong WangDepartment of Plastic and Burn Surgery, West China Hospital, Sichuan University, Chengdu, China.
Wenqing WuDepartment of Plastic and Burn Surgery, West China Hospital, Sichuan University, Chengdu, China.
Yeqian HuangDepartment of Plastic and Burn Surgery, West China Hospital, Sichuan University, Chengdu, China.
Bo PengDepartment of Plastic and Burn Surgery, West China Hospital, Sichuan University, Chengdu, China.
Jun TangDepartment of Plastic and Burn Surgery, West China Hospital, Sichuan University, Chengdu, China.
Bo PanPlastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Baoyun WangDepartment of Plastic and Burn Surgery, West China Hospital, Sichuan University, Chengdu, China.
Zhixing ChenDepartment of Plastic and Burn Surgery, West China Hospital, Sichuan University, Chengdu, China.
Zhenyu ZhangDepartment of Plastic and Burn Surgery, West China Hospital, Sichuan University, Chengdu, China.
Sichuan University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Refractory skin defects such as pressure ulcers, diabetic ulcers, and vascular ulcers represent a challenge for clinicians and researchers in many aspects. The treatment strategies for wound healing have high cost and limited efficacy. To ease the financial and psychological burden on patients, a more effective therapeutic approach is needed to address the chronic wound. MSC-derived exosomes (MSC-exosomes), the main bioactive extracellular vesicles of the paracrine effect of MSCs, have been proposed as a new potential cell-free approach for wound healing and skin regeneration. The benefits of MSC-exosomes include their ability to promote angiogenesis and cell proliferation, increase collagen production, regulate inflammation, and finally improve tissue regenerative capacity. However, poor targeting and easy removability of MSC-exosomes from the wound are major obstacles to their use in clinical therapy. Thus, the concept of bioengineering technology has been introduced to modify exosomes, enabling higher concentrations and construction of particles of greater stability with specific therapeutic capability. The use of biomaterials to load MSC-exosomes may be a promising strategy to concentrate dose, create the desired therapeutic efficacy, and maintain a sustained release effect. The beneficial role of MSC-exosomes in wound healing is been widely accepted; however, the potential of bioengineering-modified MSC-exosomes remains unclear. In this review, we attempt to summarize the therapeutic applications of modified MSC-exosomes in wound healing and skin regeneration. The challenges and prospects of bioengineered MSC-exosomes are also discussed.

Indexed as

bioengineeringexosomesmesenchymal stem cellskin regenerationwound healing

Identifiers

PMID36923255
PMCPMC10009159
OpenAlexW4322503854

What OpenQuestion holds

Textfull text, public
LicenceCC BY
reference markers read18
measurements read18
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.