ArticleFrontiers in endocrinology2023
Metabonomic analysis of follicular fluid in patients with diminished ovarian reserve.
Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Metabolomic alterations in follicular fluid across female infertility conditions in IVF: a systematic review.Journal of assisted reproduction and genetics · 2026Pooled it
- Acupuncture and related therapies for anxiety and depression in patients with premature ovarian insufficiency and diminished ovarian reserve: a systematic review and meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Growth Hormone Reverses Cisplatin-Induced Ovarian Reserve Depletion in Mice: Transcriptomic Elucidation of Mitochondrial Metabolic Reprogramming and Protein Synthesis Regulation.FASEB bioAdvances · 2026Article
- Tryptophan metabolism: A hidden regulator of female reproductive health beyond fertility.Chinese medical journal · 2026Review
- Molecular characteristics of follicular fluid in advanced maternal age women with different ovarian reserves: a multi-omics study.BMC women's health · 2026Article
- Decoding the Endometriosis-Associated Infertility Microenvironment: A Review of FTIR and Raman Spectroscopic Insights into Follicular Fluid.Current issues in molecular biology · 2026Review
- Epitranscriptomic modifications in embryonic development: insights into natural and ART-induced mechanisms and implications.Human reproduction update · 2026Review
- Metabolic dysregulation in follicular fluid is associated with adverse reproductive outcomes in women with decreased ovarian reserve.Journal of ovarian research · 2026Article
- The Impact of Endometriosis on Ovarian Reserve: A Systematic Review.International journal of women's health · 2026Review
- Genetic causal associations between serum metabolites and infertility: a Mendelian randomization study.Archives of medical science : AMS · 2026Article
- Development of a risk model for low oocyte retrieval in first-cycle IVF patients with diminished ovarian reserve: a retrospective single-center study.Reproduction & fertility · 2026Article
- Follicular Fluid Amino Acid Alterations in Endometriosis: Evidence for Oxidative Stress and Metabolic Dysregulation.Biomedicines · 2025Article
- Advancements in Sonication-Based Extraction Techniques for Ovarian Follicular Fluid Analysis: Implications for Infertility Diagnostics and Assisted Reproductive Technologies.International journal of molecular sciences · 2025Review
- Efficacy of glucocorticoids treatment in recurrent embryo implantation failure.Cell death discovery · 2025Review
- Choline-Mediated Regulation of Follicular Growth: Interplay Between Steroid Synthesis, Epigenetics, and Oocyte Development.Biology · 2025Review
- Integrated chemical exposome-metabolome profiling of follicular fluid and associations with fertility outcomes during assisted reproduction.Environment international · 2025Article
- Mass Spectrometry-Based Untargeted Metabolomics Identifies Distinct Metabolic Signatures in Infertility: A Comparative Analysis of PCOS, POR, and NOR.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Follicular Fluid Metabolomics: Tool for Predicting IVF Outcomes of Different Infertility Causes.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Chlorogenic Acid Ameliorates Chronic Unpredictable Stress-Induced Diminished Ovarian Reserve Through Ovarian Renin-Angiotensin System.Molecular nutrition & food research · 2025Article
- Associations of the levels of adipokines and cytokines in individual follicles with in vitro fertilization outcomes in women with different ovarian reserves.Journal of ovarian research · 2025Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Ovarian reserve is an important factor determining female reproductive potential. The number and quality of oocytes in patients with diminished ovarian reserve (DOR) are reduced, and even if Methods: In this research, 26 infertile women with DOR and 28 volunteers with normal ovarian reserve receiving IVF/ET were recruited, and their follicular fluid samples were collected for a nontargeted metabonomic study. The orthogonal partial least squares discriminant analysis model was used to understand the separation trend of the two groups, KEGG was used to analyze the possible metabolic pathways involved in differential metabolites, and the random forest algorithm was used to establish the diagnostic model. Results: 12 upregulated and 32 downregulated differential metabolites were detected by metabolic analysis, mainly including amino acids, indoles, nucleosides, organic acids, steroids, phospholipids, fatty acyls, and organic oxygen compounds. Through KEGG analysis, these metabolites were mainly involved in aminoacyl-tRNA biosynthesis, tryptophan metabolism, pantothenate and CoA biosynthesis, and purine metabolism. The AUC value of the diagnostic model based on the top 10 metabolites was 0.9936. Conclusion: The follicular fluid of patients with DOR shows unique metabolic characteristics. These data can provide us with rich biochemical information and a research basis for exploring the pathogenesis of DOR and predicting ovarian reserve function.
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Registered trials
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