Evidence map›Paper›PMID 36923009›Full record

ArticleFrontiers in medicine2023

Prognostication of progressive pulmonary fibrosis in connective tissue disease-associated interstitial lung diseases: A cohort study.

Yu-Hsiang Chiu, Maaike F M Koops, Mareye Voortman, H Wouter van Es, Lucianne C M Langezaal, Paco M J Welsing, Anna Jamnitski, Anne E Wind, Jacob M van Laar, Jan C Grutters and 1 more

Open access · goldFull text read
In one paragraph

Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Progressive pulmonary fibrosis: the importance of identification and intervention.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Progressive fibrotic interstitial lung disease.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2023
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Yu-Hsiang ChiuDepartment of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands.
Maaike F M KoopsDepartment of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands.
Mareye VoortmanDepartment of Pulmonology, University Medical Center Utrecht, Utrecht, Netherlands.
H Wouter van EsDepartment of Radiology, St. Antonius Hospital, Nieuwegein, Netherlands.
Lucianne C M LangezaalDepartment of Radiology, St. Antonius Hospital, Nieuwegein, Netherlands.
Paco M J WelsingDepartment of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands.
Anna JamnitskiDepartment of Rheumatology, St. Antonius Hospital, Nieuwegein, Netherlands.
Anne E WindDepartment of Pulmonology, ILD Center of Excellence, St. Antonius Hospital, Nieuwegein, Netherlands.
Jacob M van LaarDepartment of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands.
Jan C GruttersDepartment of Pulmonology, University Medical Center Utrecht, Utrecht, Netherlands.
Julia SpieringsDepartment of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands.
University Medical Center Utrecht · NLSt. Antonius Ziekenhuis · NLTri-Service General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Connective tissue diseases-associated interstitial lung disease (CTD-ILD) is a heterogeneous condition that impairs quality of life and is associated with premature death. Progressive pulmonary fibrosis (PPF) has been identified as an important risk factor for poor prognosis. However, different criteria for PPF are used in clinical studies, which may complicate comparison between trials and translation of study findings into clinical practice. Methods: This is a retrospective single center study in patients with CTD-ILD. The prognostic relevance of PPF definitions, including INBUILD, ATS/ERS/JRS/ALAT 2022, and simplified progressive fibrosing (simplified PF) criteria, were examined in this cohort and validated in the other reported Dutch CTD-ILD cohort. Results: A total of 230 patients with CTD-ILD were included and the median follow-up period was six (3-9) years. Mortality risk was independently associated with age (adjusted HR 1.07, Conclusion: Higher age, smoking, increased extent of fibrosis and low baseline DLCO were associated with poor prognosis, while regular pulmonary function evaluation was associated with better survival. The INBUILD, ATS/ERS/JRS/ALAT 2022, and simplified PF criteria revealed similar prognostication.

Indexed as

connective tissue diseasesimmune-mediated inflammatory diseasesinterstitial lung diseasesoutcome predictorspulmonary fibrosis

Identifiers

PMID36923009
PMCPMC10008854
OpenAlexW4322506668

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read98
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.