Evidence map›Paper›PMID 36922944›Full record

ArticleRSC advances2023

Each side chain of cyclosporin A is not essential for high passive permeability across lipid bilayers.

Takahiro Ono, Kazuhito V Tabata, Hiroyuki Noji, Jumpei Morimoto, Shinsuke Sando

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Takahiro OnoDepartment of Chemistry & Biotechnology, Graduate School of Engineering, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8656 Japan jmorimoto@chembio.t.u-tokyo.ac.jp ssando@chembio.t.u-tokyo.ac.jp.ORCID https://orcid.org/0000-0002-7438-2078
Kazuhito V TabataDepartment of Applied Chemistry, Graduate School of Engineering, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8656 Japan.ORCID https://orcid.org/0000-0002-0463-1374
Hiroyuki NojiDepartment of Applied Chemistry, Graduate School of Engineering, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8656 Japan.ORCID https://orcid.org/0000-0002-8842-6836
Jumpei MorimotoDepartment of Chemistry & Biotechnology, Graduate School of Engineering, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8656 Japan jmorimoto@chembio.t.u-tokyo.ac.jp ssando@chembio.t.u-tokyo.ac.jp.ORCID https://orcid.org/0000-0002-8393-9616
Shinsuke SandoDepartment of Chemistry & Biotechnology, Graduate School of Engineering, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8656 Japan jmorimoto@chembio.t.u-tokyo.ac.jp ssando@chembio.t.u-tokyo.ac.jp.ORCID https://orcid.org/0000-0003-0275-7237
The University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We compared the passive permeability of cyclosporin A (CsA) derivatives with side chain deletions across lipid bilayers. CsA maintained passive permeability after losing any one of the side chains, which suggests that the propensity of the backbone of CsA is an important component for high passive permeability.

Identifiers

PMID36922944
PMCPMC10010161
OpenAlexW4324123377

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.